{"doi":"10.1093/infdis/jiab243","title":"Baseline Asymptomatic Malaria Infection and Immunogenicity of Recombinant Vesicular Stomatitis Virus–Zaire Ebola Virus Envelope Glycoprotein","abstract":"BACKGROUND: The effect of malaria infection on the immunogenicity of the recombinant vesicular stomatitis virus-Zaire Ebola virus envelope glycoprotein (GP) vaccine (rVSVΔG-ZEBOV-GP) (ERVEBO) is unknown. METHODS: The Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE) vaccinated 7998 asymptomatic adults with rVSVΔG-ZEBOV-GP during the 2014-2016 Ebola epidemic. In STRIVE's immunogenicity substudy, participants provided blood samples at baseline and at 1, 6, and 9-12 months. Anti-GP binding and neutralizing antibodies were measured using validated assays. Baseline samples were tested for malaria parasites by polymerase chain reaction. RESULTS: Overall, 506 participants enrolled in the immunogenicity substudy and had ≥1 postvaccination antibody titer. Of 499 participants with a result, baseline malaria parasitemia was detected in 73 (14.6%). All GP enzyme-linked immunosorbent assay (ELISA) and plaque reduction neutralization test (PRNT) geometric mean titers (GMTs) at 1, 6, and 9-12 months were above baseline, and 94.1% of participants showed seroresponse by GP-ELISA (≥2-fold rise and ≥200 ELISA units/mL), while 81.5% showed seroresponse by PRNT (≥4-fold rise) at ≥1 postvaccination assessment. In participants with baseline malaria parasitemia, the PRNT seroresponse proportion was lower, while PRNT GMTs and GP-ELISA seroresponse and GMTs showed a trend toward lower responses at 6 and 9-12 months. CONCLUSION: Asymptomatic adults with or without malaria parasitemia had robust immune responses to rVSVΔG-ZEBOV-GP, persisting for 9-12 months. Responses in those with malaria parasitemia were somewhat lower.","journal":"The Journal of Infectious Diseases","year":2021,"id":179434,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":727771,"name":"Jakub K. Simon","orcid":null,"position":1,"is_corresponding":false},{"id":227044,"name":"Marc‐Alain Widdowson","orcid":"0000-0002-0682-6933","position":2,"is_corresponding":false},{"id":479793,"name":"Mohamed Samai","orcid":"0000-0002-1427-9482","position":3,"is_corresponding":false},{"id":590125,"name":"Eric Rogier","orcid":"0000-0001-7375-8304","position":4,"is_corresponding":false},{"id":480329,"name":"Jennifer Legardy-Williams","orcid":null,"position":5,"is_corresponding":false},{"id":726912,"name":"Kenneth Liu","orcid":"0000-0002-4107-7296","position":6,"is_corresponding":false},{"id":243251,"name":"Jarad Schiffer","orcid":"0000-0003-3193-2700","position":7,"is_corresponding":false},{"id":43917,"name":"J. Lange","orcid":"0000-0002-2450-1366","position":8,"is_corresponding":false},{"id":419920,"name":"Carolynn DeByle","orcid":"0000-0003-2711-4588","position":9,"is_corresponding":false},{"id":727772,"name":"Robert W. Pinner","orcid":null,"position":10,"is_corresponding":false},{"id":727773,"name":"Anne Schuchat","orcid":null,"position":11,"is_corresponding":false},{"id":349726,"name":"Laurence Slutsker","orcid":null,"position":12,"is_corresponding":false},{"id":726913,"name":"Susan Goldstein","orcid":"0000-0002-3424-5319","position":13,"is_corresponding":false},{"id":480332,"name":"Barbara E. Mahon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:47:48.974996Z","pmid":"34013349","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}