{"doi":"10.1093/infdis/jiab155","title":"Correlation Between TIGIT Expression on CD8+ T Cells and Higher Cytotoxic Capacity","abstract":"Persistent exposure to antigen leads to T-cell exhaustion and immunologic dysfunction. We examined the immune exhaustion markers T cell immunoglobulin and ITIM domain (TIGIT) and programmed cell death protein 1 (PD-1) in human immunodeficiency virus (HIV)-infected and healthy individuals and the relationship with cytotoxic CD8+ T-lymphocyte activity. Frequencies of TIGIT but not PD-1 were positively correlated with CD8+ T-lymphocyte activity in HIV-aviremic and healthy individuals; however, there was no correlation in HIV-viremic individuals. Transcriptome analyses revealed up-regulation of genes associated with antiviral immunity in TIGIT+CD8+ versus TIGIT-CD8+ T cells. Our data suggest that TIGIT+CD8+ T cells do not necessarily represent a state of immune exhaustion and maintain an intrinsic cytotoxicity in HIV-infected individuals.","journal":"The Journal of Infectious Diseases","year":2021,"id":186635,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9637,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471706,"name":"Erin Huiting","orcid":"0000-0002-5454-2679","position":1,"is_corresponding":false},{"id":244964,"name":"Arun K. Boddapati","orcid":"0000-0002-7661-8443","position":2,"is_corresponding":false},{"id":471709,"name":"Victoria Shi","orcid":"0000-0001-6568-3007","position":3,"is_corresponding":false},{"id":472479,"name":"Emily J. Whitehead","orcid":null,"position":4,"is_corresponding":false},{"id":472478,"name":"J. Shawn Justement","orcid":null,"position":5,"is_corresponding":false},{"id":439168,"name":"Jeffrey L. Nordstrom","orcid":null,"position":6,"is_corresponding":false},{"id":245106,"name":"Susan Moir","orcid":"0000-0002-0163-6911","position":7,"is_corresponding":false},{"id":261946,"name":"Justin Lack","orcid":"0000-0003-0584-4010","position":8,"is_corresponding":false},{"id":228710,"name":"Tae‐Wook Chun","orcid":"0000-0001-5153-7340","position":9,"is_corresponding":false},{"id":387593,"name":"Jana Blažková","orcid":"0000-0002-6000-202X","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-18T23:48:46.850806Z","pmid":"33744939","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}