{"doi":"10.1093/infdis/jiab078","title":"Reply to Lai et al","abstract":"To the Editor—We read with interest the letter by Lai et al [1] in response to our article on adjunctive host-directed therapy with statins for tuberculosis in preclinical models [2]. The authors have sought to assess potential differences among various statins, including atorvastatin, simvastatin, rosuvastatin, fluvastatin, and pravastatin, in their ability to prevent tuberculosis. They performed a population-based, nested case-control study of patients with active tuberculosis as case patients and healthy individuals as controls. Case patients and controls were matched by age, sex, and time of study recruitment. The authors performed regression analysis with very rigorous methods to control for all potential confounders. Lai et al found that current statin use (ie, statin prescription filled within 30 days of the index date) was associated with a reduced risk of active tuberculosis, with an adjusted rate ratio of 0.79 (95% confidence interval [CI], .68–.92) [1...","journal":"The Journal of Infectious Diseases","year":2021,"id":218378,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":333926,"name":"Petros C. Karakousis","orcid":"0000-0003-1338-9206","position":1,"is_corresponding":false},{"id":378802,"name":"Vignesh Chidambaram","orcid":"0000-0002-4240-1027","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:53:29.626149Z","pmid":"33580262","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}