{"doi":"10.1093/infdis/jiaa781","title":"Intensive Care Unit–Like Care of Nonhuman Primates with Ebola Virus Disease","abstract":"BACKGROUND: Ebola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhuman primate (NHP) model. METHODS: Fourteen rhesus macaques were challenged intramuscularly with a target dose of Ebola virus (1000 plaque-forming units; Kikwit). NHPs were allocated to intensive care unit (ICU)-like algorithms (n = 7), intravenous fluids plus levofloxacin (n = 2), or a control group (n = 5). The primary outcome measure was duration of survival, and secondary outcomes included changes in clinical laboratory values. RESULTS: Duration of survival was not significantly different between the pooled ICU-like algorithm and control groups (8.2 vs 6.9 days of survival; hazard ratio; 0.50; P = .25). Norepinephrine was effective in transiently maintaining baseline blood pressure. NHPs treated with ICU-like algorithms had delayed onset of liver and kidney injury. CONCLUSIONS: While an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement.","journal":"The Journal of Infectious Diseases","year":2020,"id":74946,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":391332,"name":"Mark G. Kortepeter","orcid":"0000-0001-7873-3587","position":1,"is_corresponding":false},{"id":391919,"name":"Lydia G Downey","orcid":null,"position":2,"is_corresponding":false},{"id":391920,"name":"Cristian Madar","orcid":null,"position":3,"is_corresponding":false},{"id":391333,"name":"Isaac Downs","orcid":"0000-0002-5106-3832","position":4,"is_corresponding":false},{"id":325407,"name":"Karen Martins","orcid":"0000-0001-6536-3492","position":5,"is_corresponding":false},{"id":138983,"name":"Franco Rossi","orcid":null,"position":6,"is_corresponding":false},{"id":391334,"name":"Janice A. Williams","orcid":"0000-0002-2443-7894","position":7,"is_corresponding":false},{"id":391921,"name":"Annie Madar","orcid":null,"position":8,"is_corresponding":false},{"id":391922,"name":"Christopher W. Schellhase","orcid":null,"position":9,"is_corresponding":false},{"id":391335,"name":"Jeremy J. Bearss","orcid":"0000-0002-4280-5670","position":10,"is_corresponding":false},{"id":325393,"name":"Xiankun Zeng","orcid":"0000-0003-3526-8755","position":11,"is_corresponding":false},{"id":235594,"name":"Sina Bavari","orcid":"0000-0001-8424-5635","position":12,"is_corresponding":false},{"id":306712,"name":"Veronica Soloveva","orcid":null,"position":13,"is_corresponding":false},{"id":391923,"name":"Jay Wells","orcid":null,"position":14,"is_corresponding":false},{"id":391924,"name":"Kelly S. Stuthman","orcid":null,"position":15,"is_corresponding":false},{"id":391925,"name":"Nicole L. 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