{"doi":"10.1093/infdis/jiaa758","title":"Association of Serum 25-Hydroxyvitamin D With Prevalence, Incidence, and Clearance of Vaginal HPV Infection in Young Women","abstract":"BACKGROUND: We assessed the association between serum 25-hydroxyvitamin D levels and genital human papillomavirus (HPV) prevalence, incidence, and clearance among female participants in the HPV Infection and Transmission among Couples through Heterosexual activity (HITCH) Cohort Study. METHODS: We genotyped HPV DNA in vaginal samples and quantified baseline serum 25-hydroxyvitamin D levels using Roche's Linear Array and Total vitamin D assay, respectively. We used logistic and Cox proportional hazards models, respectively, to estimate adjusted odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: There was no association between vitamin D levels (every 10-ng/mL increase) at baseline and HPV prevalence (OR, 0.88; 95% CI, .73-1.03) or incidence (HR, 0.88; 95% CI, .73-1.06), but we observed a modest negative association with HPV clearance (HR, 0.76; 95% CI, .60-.96). Vitamin D levels <30 ng/mL, compared with those ≥30 ng/mL, were not associated with HPV prevalence (OR, 0.98; 95% CI, .57-1.69) or incidence (HR, .87; 95% CI, .50-1.43), but they were associated with a marginally significant increased clearance (OR, 2.14; 95% CI, .99-4.64). We observed consistent results with restricted cubic spline modeling of vitamin D levels and clinically defined categories. HPV type-specific analyses accounting for multiple HPV infections per participant showed no association between vitamin D levels and all study outcomes. CONCLUSIONS: This study provided no evidence of an association between low vitamin D levels and increased HPV prevalence, acquisition, or clearance.","journal":"The Journal of Infectious Diseases","year":2020,"id":106926,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.905,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":514978,"name":"Farzin Khosrow‐Khavar","orcid":"0000-0003-3636-8918","position":1,"is_corresponding":false},{"id":341044,"name":"Ann N. Burchell","orcid":null,"position":2,"is_corresponding":false},{"id":514979,"name":"Pierre‐Paul Tellier","orcid":"0000-0001-8009-4120","position":3,"is_corresponding":false},{"id":515627,"name":"Shaun Eintracht","orcid":null,"position":4,"is_corresponding":false},{"id":515628,"name":"Elizabeth McNamara","orcid":null,"position":5,"is_corresponding":false},{"id":514980,"name":"François Coutlée","orcid":"0000-0003-0507-3236","position":6,"is_corresponding":false},{"id":506891,"name":"Eduardo L. Franco","orcid":"0000-0002-4409-8084","position":7,"is_corresponding":false},{"id":515629,"name":"for the HITCH study group","orcid":null,"position":8,"is_corresponding":false},{"id":515630,"name":"Allita Rodrigues","orcid":null,"position":9,"is_corresponding":false},{"id":515631,"name":"Gail Kelsall","orcid":null,"position":10,"is_corresponding":false},{"id":515632,"name":"Suzanne Dumais","orcid":null,"position":11,"is_corresponding":false},{"id":515633,"name":"Natalia Morykon","orcid":null,"position":12,"is_corresponding":false},{"id":515634,"name":"Amelia Rocamora","orcid":null,"position":13,"is_corresponding":false},{"id":515635,"name":"Nathalie Slavtcheva","orcid":null,"position":14,"is_corresponding":false},{"id":515636,"name":"Veronika Moravan","orcid":null,"position":15,"is_corresponding":false},{"id":515637,"name":"Michel Wissing","orcid":null,"position":16,"is_corresponding":false},{"id":241587,"name":"Michel Roger","orcid":"0000-0002-5810-1555","position":17,"is_corresponding":false},{"id":514977,"name":"Mariam El‐Zein","orcid":"0000-0002-5190-0370","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:12:31.053776Z","pmid":"33306088","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}