{"doi":"10.1093/infdis/jiaa717","title":"The Effect of IL-6 Inhibitors on Mortality Among Hospitalized COVID-19 Patients: A Multicenter Study","abstract":"BACKGROUND: The effectiveness of interleukin-6 inhibitors (IL-6i) in ameliorating coronavirus disease 2019 (COVID-19) remains uncertain. METHODS: We analyzed data for patients aged ≥18 years admitted with a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test at 4 safety-net hospital systems with diverse populations and high rates of medical comorbidities in 3 US regions. We used inverse probability of treatment weighting via machine learning for confounding adjustment by demographics, comorbidities, and disease severity markers. We estimated the average treatment effect, the odds of IL-6i effect on in-hospital mortality from COVID-19, using a logistic marginal structural model. RESULTS: Of 516 patients, 104 (20.1%) received IL-6i. Estimate of the average treatment effect adjusted for confounders suggested a 37% reduction in odds of in-hospital mortality in those who received IL-6i compared with those who did not, although the confidence interval included the null value of 1 (odds ratio = 0.63; 95% confidence interval, .29-1.38). A sensitivity analysis suggested that potential unmeasured confounding would require a minimum odds ratio of 2.55 to nullify our estimated IL-6i effect size. CONCLUSIONS: Despite low precision, our findings suggested a relatively large effect size of IL-6i in reducing the odds of COVID-19-related in-hospital mortality.","journal":"The Journal of Infectious Diseases","year":2020,"id":106852,"datarank":0.5228234250426564,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.210907193790681,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.210907193790681,"corpus_percentile":62.98445114875841,"corpus_rank":4786,"citation_count":7,"citer_count":7,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6445,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267435,"name":"S. Reza Jafarzadeh","orcid":"0000-0002-1099-9175","position":1,"is_corresponding":false},{"id":312537,"name":"Sabrina A. Assoumou","orcid":"0000-0002-5169-620X","position":2,"is_corresponding":false},{"id":312532,"name":"Catherine Bielick","orcid":"0000-0003-1871-3909","position":3,"is_corresponding":false},{"id":515561,"name":"Bethanne Carpenter","orcid":null,"position":4,"is_corresponding":false},{"id":395152,"name":"Shivani Garg","orcid":"0000-0001-7272-2692","position":5,"is_corresponding":false},{"id":515562,"name":"Sahni Harleen","orcid":null,"position":6,"is_corresponding":false},{"id":55625,"name":"Tuhina Neogi","orcid":"0000-0002-9515-1711","position":7,"is_corresponding":false},{"id":160479,"name":"M. Nishio","orcid":null,"position":8,"is_corresponding":false},{"id":231606,"name":"Manish Sagar","orcid":"0000-0001-9803-6594","position":9,"is_corresponding":false},{"id":515563,"name":"Veronika Sharp","orcid":null,"position":10,"is_corresponding":false},{"id":514837,"name":"Eugene Y. Kissin","orcid":"0000-0002-7748-3384","position":11,"is_corresponding":false},{"id":231610,"name":"Pranay Sinha","orcid":"0000-0002-4233-0871","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"33216906","pmcid":"PMC7717300","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}