{"doi":"10.1093/infdis/jiaa584","title":"Contribution of Staphylococcal Enterotoxin B to<i>Staphylococcus aureus</i>Systemic Infection","abstract":"Staphylococcal enterotoxin B (SEB), which is produced by the major human pathogen, Staphylococcus aureus, represents a powerful superantigenic toxin and is considered a bioweapon. However, the contribution of SEB to S. aureus pathogenesis has never been directly demonstrated with genetically defined mutants in clinically relevant strains. Many isolates of the predominant Asian community-associated methicillin-resistant S. aureus lineage sequence type (ST) 59 harbor seb, implying a significant role of SEB in the observed hypervirulence of this lineage. We created an isogenic seb mutant in a representative ST59 isolate and assessed its virulence potential in mouse infection models. We detected a significant contribution of seb to systemic ST59 infection that was associated with a cytokine storm. Our results directly demonstrate that seb contributes to S. aureus pathogenesis, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, they indicate that seb contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection.","journal":"The Journal of Infectious Diseases","year":2020,"id":61793,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":326521,"name":"Fei Da","orcid":"0000-0002-5330-5962","position":1,"is_corresponding":false},{"id":326522,"name":"Ryan Liu","orcid":"0009-0001-2766-2341","position":2,"is_corresponding":false},{"id":268485,"name":"Lei He","orcid":"0000-0002-0215-3102","position":3,"is_corresponding":false},{"id":269582,"name":"Huiying Lv","orcid":null,"position":4,"is_corresponding":false},{"id":326523,"name":"Emilie L. Fisher","orcid":"0000-0001-9186-7512","position":5,"is_corresponding":false},{"id":326524,"name":"Govindarajan Rajagopalan","orcid":"0000-0003-2608-8162","position":6,"is_corresponding":false},{"id":326525,"name":"Min Li","orcid":"0000-0003-4754-8009","position":7,"is_corresponding":false},{"id":326526,"name":"Gordon Y. C. Cheung","orcid":"0000-0003-1796-6058","position":8,"is_corresponding":false},{"id":268488,"name":"Michaël Otto","orcid":"0000-0002-2222-4115","position":9,"is_corresponding":false},{"id":326520,"name":"Justin S. Bae","orcid":"0000-0002-7166-9030","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T21:09:47.114172Z","pmid":"32937658","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}