{"doi":"10.1093/infdis/jiaa557","title":"Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior","abstract":"BACKGROUND: Understanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination. METHODS: We conducted a prospective cohort study in Baltimore, Maryland. Women aged 35-60 years underwent HPV testing and completed health and sexual behavior questionnaires every 6 months over a 2-year period. New detection/loss of detection rates were calculated and adjusted hazard ratios were used to identify risk factors for new detection. RESULTS: The new and loss of detection analyses included 731 women, and 104 positive for high-risk HPV. The rate of new high-risk HPV detection was 5.0 per 1000 woman-months. Reporting a new sex partner was associated with higher detection rates (adjusted hazard ratio, 8.1; 95% confidence interval, 3.5-18.6), but accounted only for 19.4% of all new detections. Among monogamous and sexually abstinent women, new detection was higher in women reporting ≥5 lifetime sexual partners than in those reporting <5 (adjusted hazard ratio, 2.2; 95% confidence interval, 1.2-4.2). CONCLUSION: Although women remain at risk of HPV acquisition from new sex partners as they age, our results suggest that most new detections in middle-aged women reflect recurrence of previously acquired HPV.","journal":"The Journal of Infectious Diseases","year":2020,"id":92543,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":195714,"name":"Anne Hammer","orcid":"0000-0002-4616-9827","position":1,"is_corresponding":false},{"id":267123,"name":"Anne F. Rositch","orcid":"0000-0002-0403-8482","position":2,"is_corresponding":false},{"id":463040,"name":"Anne E. Burke","orcid":"0009-0009-4849-1068","position":3,"is_corresponding":false},{"id":366077,"name":"Raphael P. Viscidi","orcid":"0000-0002-7906-8002","position":4,"is_corresponding":false},{"id":463041,"name":"Michelle I. Silver","orcid":"0000-0002-2678-3539","position":5,"is_corresponding":false},{"id":463042,"name":"Nicole G. Campos","orcid":"0000-0002-0840-4339","position":6,"is_corresponding":false},{"id":320947,"name":"Ada O. Youk","orcid":"0000-0001-6912-9759","position":7,"is_corresponding":false},{"id":339254,"name":"Patti E. Gravitt","orcid":"0000-0002-3007-3425","position":8,"is_corresponding":false},{"id":463039,"name":"Proma Paul","orcid":"0000-0003-0258-1040","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T22:30:31.563852Z","pmid":"32870982","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}