{"doi":"10.1093/infdis/jiaa480","title":"Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults","abstract":"BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.","journal":"The Journal of Infectious Diseases","year":2020,"id":66905,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106960,"name":"Graham Pawelec","orcid":"0000-0002-3600-0163","position":1,"is_corresponding":false},{"id":21721,"name":"Stella Trompet","orcid":"0000-0001-5006-0528","position":2,"is_corresponding":false},{"id":354238,"name":"David Goldeck","orcid":"0000-0001-6220-1527","position":3,"is_corresponding":false},{"id":354239,"name":"Laust Hvas Mortensen","orcid":"0000-0002-6399-495X","position":4,"is_corresponding":false},{"id":21982,"name":"P. Eline Slagboom","orcid":"0000-0002-2875-4723","position":5,"is_corresponding":false},{"id":38571,"name":"Kaare Christensen","orcid":"0000-0002-5429-5292","position":6,"is_corresponding":false},{"id":291480,"name":"Jacobijn Gussekloo","orcid":"0000-0001-7186-8278","position":7,"is_corresponding":false},{"id":88701,"name":"Patricia M. Kearney","orcid":"0000-0001-9599-3540","position":8,"is_corresponding":false},{"id":21741,"name":"Brendan M. Buckley","orcid":"0000-0003-1544-8003","position":9,"is_corresponding":false},{"id":21874,"name":"Ian Ford","orcid":"0000-0001-5927-1823","position":10,"is_corresponding":false},{"id":21963,"name":"J. Wouter Jukema","orcid":"0000-0002-3246-8359","position":11,"is_corresponding":false},{"id":354240,"name":"Rudi G. J. Westendorp","orcid":"0000-0002-0672-8372","position":12,"is_corresponding":false},{"id":264262,"name":"Andrea B. Maier","orcid":"0000-0001-7206-1724","position":13,"is_corresponding":false},{"id":354237,"name":"Sijia Chen","orcid":"0000-0001-8966-3422","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:14:50.590588Z","pmid":"32909605","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}