{"doi":"10.1093/infdis/jiaa419","title":"A Chronic Murine Disease Model of Coccidioidomycosis Using <i>Coccidioides posadasii</i>, Strain 1038","abstract":"Murine infections with most Coccidioides spp. strains are lethal by 3 weeks, limiting the study of immune responses. Coccidioides posadasii, strain 1038 (Cp1038), while slowly lethal, resulted in protracted survival of C57BL/6 (B6) mice. In resistant (B6D2)F1/J mice, lung fungal burdens stabilized by week 4 without progression through week 16, better modeling human coccidioidal infections after their immunologic control. Immunodeficient tumor necrosis factor (Tnf) α knockout (KO) and interferon (Ifn) γ receptor 1 (Ifn-γr1) KO mice survived a median of 22.5 and 34 days, compared with 70 days in B6 mice (P = .001 and P < .01, respectively), though 14-day lung fungal burden studies showed little difference between Ifn-γr1 KO and B6 mice. B6 mice showed peak concentrations of key inflammatory lung cytokines, including interleukin 6, 23, and 17A, Tnf-α, and Ifn-γ, only after 4 weeks of infection. The slower progression in B6 and the acquired fungal burden stability in B6D2 mice after Cp1038 infection greatly increases the array of possible immunologic studies.","journal":"The Journal of Infectious Diseases","year":2020,"id":103279,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":503256,"name":"Daniel A. Powell","orcid":"0000-0003-0503-3330","position":1,"is_corresponding":false},{"id":503257,"name":"Christine D. Butkiewicz","orcid":"0000-0001-5019-7567","position":2,"is_corresponding":false},{"id":389368,"name":"Maria L. Lewis","orcid":null,"position":3,"is_corresponding":false},{"id":503258,"name":"Hien T. Trinh","orcid":"0000-0002-7744-799X","position":4,"is_corresponding":false},{"id":503259,"name":"Jeffrey A. Frelinger","orcid":"0000-0002-2503-6267","position":5,"is_corresponding":false},{"id":482432,"name":"Marc J. Orbach","orcid":"0000-0001-7714-1352","position":6,"is_corresponding":false},{"id":387999,"name":"John N. Galgiani","orcid":"0000-0002-7882-1883","position":7,"is_corresponding":false},{"id":503255,"name":"Lisa F. Shubitz","orcid":"0000-0003-1011-0708","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T22:42:17.920911Z","pmid":"32658292","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}