{"doi":"10.1093/infdis/jiaa396","title":"The Impact of Immunosuppression on Chronic Kidney Disease in People Living With Human Immunodeficiency Virus: The D:A:D Study","abstract":"BACKGROUND: Relations between different measures of human immunodeficiency virus-related immunosuppression and chronic kidney disease (CKD) remain unknown. METHODS: Immunosuppression measures included baseline, current, time-lagged and nadir CD4, years and percentage of follow-up (%FU) with CD4 ≤200 cells/μL, and CD4 recovery. CKD was defined as confirmed estimated glomerular filtration rate <60 mL/minute/1.73 m2. RESULTS: Of 33 791 persons, 2226 developed CKD. Univariably, all immunosuppression measures predicted CKD. Multivariably, the strongest predictor was %FU CD4 ≤200 cells/μL (0 vs >25%; incidence rate ratio [IRR], 0.77 [95% confidence interval [CI], .68-.88]), with highest effect in those at low D:A:D CKD risk (IRR, 0.45 [95% CI, .24-.80]) vs 0.80 [95% CI, .70-.93]). CONCLUSIONS: Longer immunosuppression duration most strongly predicts CKD and affects persons at low CKD risk more.","journal":"The Journal of Infectious Diseases","year":2020,"id":106480,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":12038,"name":"Jens Lundgren","orcid":"0000-0001-8901-7850","position":1,"is_corresponding":false},{"id":241759,"name":"Peter Reiss","orcid":"0000-0001-7896-6428","position":2,"is_corresponding":false},{"id":514262,"name":"Mike Ross","orcid":null,"position":3,"is_corresponding":false},{"id":513590,"name":"Ole Kirk","orcid":"0000-0003-1995-1837","position":4,"is_corresponding":false},{"id":514263,"name":"Christophe Fux","orcid":null,"position":5,"is_corresponding":false},{"id":514264,"name":"Phillipe Morlat","orcid":null,"position":6,"is_corresponding":false},{"id":364620,"name":"Éric Fontas","orcid":"0000-0002-1849-9626","position":7,"is_corresponding":false},{"id":364598,"name":"Colette Smith","orcid":"0000-0003-2847-3355","position":8,"is_corresponding":false},{"id":365635,"name":"Stéphane De Wit","orcid":null,"position":9,"is_corresponding":false},{"id":364601,"name":"Antonella d’Arminio Monforte","orcid":"0000-0003-0073-1789","position":10,"is_corresponding":false},{"id":12081,"name":"Wafaa El‐Sadr","orcid":"0000-0003-3735-9781","position":11,"is_corresponding":false},{"id":513591,"name":"Camilla Ingrid Hatleberg","orcid":"0000-0002-4396-6281","position":12,"is_corresponding":false},{"id":369297,"name":"Andrew Phillips","orcid":"0000-0003-2384-4807","position":13,"is_corresponding":false},{"id":369298,"name":"Caroline Sabin","orcid":"0000-0001-5173-2760","position":14,"is_corresponding":false},{"id":11862,"name":"Matthew Law","orcid":"0000-0002-3540-8837","position":15,"is_corresponding":false},{"id":364614,"name":"Amanda Mocroft","orcid":"0000-0001-8316-1122","position":16,"is_corresponding":false},{"id":364591,"name":"Lene Ryom","orcid":"0000-0002-6436-6461","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-18T23:12:27.124515Z","pmid":"32640015","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}