{"doi":"10.1093/infdis/jiaa348","title":"Detection of Respiratory Syncytial Virus or Rhinovirus Weeks After Hospitalization for Bronchiolitis and the Risk of Recurrent Wheezing","abstract":"BACKGROUND: In severe bronchiolitis, it is unclear if delayed clearance or sequential infection of respiratory syncytial virus (RSV) or rhinovirus (RV) is associated with recurrent wheezing. METHODS: In a 17-center severe bronchiolitis cohort, we tested nasopharyngeal aspirates (NPA) upon hospitalization and 3 weeks later (clearance swab) for respiratory viruses using PCR. The same RSV subtype or RV genotype in NPA and clearance swab defined delayed clearance (DC); a new RSV subtype or RV genotype at clearance defined sequential infection (SI). Recurrent wheezing by age 3 years was defined per national asthma guidelines. RESULTS: Among 673 infants, RSV DC and RV DC were not associated with recurrent wheezing, and RSV SI was rare. The 128 infants with RV SI (19%) had nonsignificantly higher risk of recurrent wheezing (hazard ratio [HR], 1.31; 95% confidence interval [CI], .95-1.80; P = .10) versus infants without RV SI. Among infants with RV at hospitalization, those with RV SI had a higher risk of recurrent wheezing compared to children without RV SI (HR, 2.49; 95% CI, 1.22-5.06; P = .01). CONCLUSIONS: Among infants with severe bronchiolitis, those with RV at hospitalization followed by a new RV infection had the highest risk of recurrent wheezing.","journal":"The Journal of Infectious Diseases","year":2020,"id":79515,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9643,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342209,"name":"Ruth J. Geller","orcid":"0000-0001-8828-0761","position":1,"is_corresponding":false},{"id":242824,"name":"Kohei Hasegawa","orcid":"0000-0002-5739-7999","position":2,"is_corresponding":false},{"id":236976,"name":"Pedro A. Piedra","orcid":"0000-0002-5839-0879","position":3,"is_corresponding":false},{"id":236974,"name":"Vasanthi Avadhanula","orcid":"0000-0003-4016-7588","position":4,"is_corresponding":false},{"id":110411,"name":"James E. Gern","orcid":"0000-0002-6667-4708","position":5,"is_corresponding":false},{"id":306775,"name":"Yury A. Bochkov","orcid":"0000-0003-2618-4496","position":6,"is_corresponding":false},{"id":363396,"name":"Janice A. Espinola","orcid":"0000-0002-1871-973X","position":7,"is_corresponding":false},{"id":406312,"name":"Ashley F. Sullivan","orcid":"0000-0001-6783-1720","position":8,"is_corresponding":false},{"id":242827,"name":"Carlos A. Camargo","orcid":"0000-0002-5071-7654","position":9,"is_corresponding":false},{"id":311922,"name":"Jonathan M. Mansbach","orcid":"0000-0002-9176-0325","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T21:50:57.971597Z","pmid":"32564083","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}