{"doi":"10.1093/infdis/jiaa328","title":"Human Immunodeficiency Virus–Associated Myocardial Diastolic Dysfunction and Soluble ST2 Concentration in Tanzanian Adults: A Cross-Sectional Study","abstract":"BACKGROUND: The aims of this study were (1) to compare the prevalence of myocardial diastolic dysfunction (DD) in antiretroviral therapy (ART)-naive people living with human immunodeficiency virus (PLWH) to human immunodeficiency virus (HIV)-uninfected adults in East Africa and (2) to determine the association between serum concentration of the cardiac biomarkers ST2 and DD. METHODS: In this cross-sectional study, we enrolled PLWH and uninfected adults at a referral HIV clinic in Mwanza, Tanzania. Standardized history, echocardiography, and serum were obtained. Regression models were used to quantify associations. RESULTS: We enrolled 388 ART-naive PLWH and 461 HIV-uninfected adults with an average age of 36.0 ± 10.2 years. Of PLWH in the third, fourth, and fifth decades of life, 5.0%, 12.5%, and 32.7%, respectively, had DD. PLWH had a higher prevalence of DD (adjusted odds ratio, 2.71 [95% confidence interval, 1.62-4.55]; P < .0001). PLWH also had a higher probability of dysfunction with one or fewer traditional risk factors present. Serum ST2 concentration was associated with dysfunction in PLWH but not uninfected participants (P = .04 and P = .90, respectively). CONCLUSIONS: In a large population of young adults in sub-Saharan Africa, DD prevalence increased starting in the third decade of life. HIV was independently associated with dysfunction. Serum ST2 concentration was associated with DD in PLWH but not HIV-uninfected participants. This pathway may provide insight into the mechanisms of HIV-associated dysfunction.","journal":"The Journal of Infectious Diseases","year":2020,"id":72057,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":228353,"name":"Parag Goyal","orcid":"0000-0001-7474-3737","position":1,"is_corresponding":false},{"id":381966,"name":"Rahul Hosalli","orcid":null,"position":2,"is_corresponding":false},{"id":340501,"name":"Myung Hee Lee","orcid":"0000-0002-2909-4421","position":3,"is_corresponding":false},{"id":341164,"name":"Bernard Desderius","orcid":null,"position":4,"is_corresponding":false},{"id":380453,"name":"Fredrick Kalokola","orcid":"0000-0001-7926-2975","position":5,"is_corresponding":false},{"id":340500,"name":"Abel Makubi","orcid":"0000-0002-0866-6726","position":6,"is_corresponding":false},{"id":381967,"name":"Salama Fadhil","orcid":null,"position":7,"is_corresponding":false},{"id":340502,"name":"Saidi Kapiga","orcid":"0000-0003-1753-4060","position":8,"is_corresponding":false},{"id":381968,"name":"Dipan Karmali","orcid":null,"position":9,"is_corresponding":false},{"id":380454,"name":"Daniel Kaminstein","orcid":"0009-0000-2409-525X","position":10,"is_corresponding":false},{"id":55691,"name":"Richard B. Devereux","orcid":null,"position":11,"is_corresponding":false},{"id":380455,"name":"Margaret L. McNairy","orcid":"0000-0001-7853-633X","position":12,"is_corresponding":false},{"id":381969,"name":"Warren D. Johnson","orcid":null,"position":13,"is_corresponding":false},{"id":380456,"name":"Daniel W. Fitzgerald","orcid":"0000-0003-1765-0598","position":14,"is_corresponding":false},{"id":332197,"name":"Robert N. Peck","orcid":"0000-0002-4526-2480","position":15,"is_corresponding":false},{"id":340499,"name":"Justin R. Kingery","orcid":"0000-0002-6788-1231","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T21:44:45.622639Z","pmid":"32526008","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}