{"doi":"10.1093/infdis/jiaa268","title":"Ebola-Specific CD8+ and CD4+ T-Cell Responses in Sierra Leonean Ebola Virus Survivors With or Without Post-Ebola Sequelae","abstract":"BACKGROUND: Ebola virus (EBOV) disease has killed thousands of West and Central Africans over the past several decades. Many who survive the acute disease later experience post-Ebola syndrome, a constellation of symptoms whose causative pathogenesis is unclear. METHODS: We investigated EBOV-specific CD8+ and CD4+ T-cell responses in 37 Sierra Leonean EBOV disease survivors with (n = 19) or without (n = 18) sequelae of arthralgia and ocular symptoms. Peripheral blood mononuclear cells were infected with recombinant vesicular stomatitis virus encoding EBOV antigens. We also studied the presence of EBOV-specific immunoglobulin G, antinuclear antibodies, anti-cyclic citrullinated peptide antibodies, rheumatoid factor, complement levels, and cytokine levels in these 2 groups. RESULTS: Survivors with sequelae had a significantly higher EBOV-specific CD8+ and CD4+ T-cell response. No differences in EBOV-specific immunoglobulin G, antinuclear antibody, or anti-cyclic citrullinated peptide antibody levels were found. Survivors with sequelae showed significantly higher rheumatoid factor levels. CONCLUSION: EBOV-specific CD8+ and CD4+ T-cell responses were significantly higher in Ebola survivors with post-Ebola syndrome. These findings suggest that pathogenesis may occur as an immune-mediated disease via virus-specific T-cell immune response or that persistent antigen exposure leads to increased and sustained T-cell responses.","journal":"The Journal of Infectious Diseases","year":2020,"id":68356,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":362008,"name":"Saori Sakabe","orcid":"0000-0002-1619-8678","position":1,"is_corresponding":false},{"id":62139,"name":"Lansana Kanneh","orcid":null,"position":2,"is_corresponding":false},{"id":251089,"name":"Mambu Momoh","orcid":"0000-0001-7091-1027","position":3,"is_corresponding":false},{"id":363048,"name":"Foday Al-Hassan","orcid":null,"position":4,"is_corresponding":false},{"id":363049,"name":"Mohamed Yilah","orcid":null,"position":5,"is_corresponding":false},{"id":338514,"name":"Augustine Goba","orcid":null,"position":6,"is_corresponding":false},{"id":251088,"name":"John Demby Sandi","orcid":"0000-0002-7474-8156","position":7,"is_corresponding":false},{"id":338515,"name":"Michael Gbakie","orcid":null,"position":8,"is_corresponding":false},{"id":227986,"name":"Beatrice Cubitt","orcid":"0000-0002-8048-410X","position":9,"is_corresponding":false},{"id":251092,"name":"Matthew L. Boisen","orcid":"0000-0001-6043-8459","position":10,"is_corresponding":false},{"id":333778,"name":"Jessica Mayeux","orcid":"0000-0001-7335-6807","position":11,"is_corresponding":false},{"id":363050,"name":"Ashley R. Smira","orcid":null,"position":12,"is_corresponding":false},{"id":363051,"name":"Kayla R Shore","orcid":null,"position":13,"is_corresponding":false},{"id":363052,"name":"Iris Bica","orcid":null,"position":14,"is_corresponding":false},{"id":135552,"name":"K. Michael Pollard","orcid":null,"position":15,"is_corresponding":false},{"id":227994,"name":"Juan Carlos de la Torre","orcid":"0000-0002-8171-8115","position":16,"is_corresponding":false},{"id":251091,"name":"Luis M. Branco","orcid":"0000-0001-8161-0182","position":17,"is_corresponding":false},{"id":62204,"name":"Robert F. Garry","orcid":"0000-0002-5683-3250","position":18,"is_corresponding":false},{"id":251097,"name":"Donald S. Grant","orcid":"0000-0002-4329-0795","position":19,"is_corresponding":false},{"id":62205,"name":"John S. Schieffelin","orcid":"0000-0001-6642-5739","position":20,"is_corresponding":false},{"id":362009,"name":"Michael B. A. Oldstone","orcid":"0000-0003-0804-0501","position":21,"is_corresponding":false},{"id":251093,"name":"Brian M. Sullivan","orcid":"0000-0003-4277-6037","position":22,"is_corresponding":false},{"id":362007,"name":"Stephanie M. LaVergne","orcid":"0000-0001-5902-1154","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"32436943","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}