{"doi":"10.1093/infdis/jiaa254","title":"Hepatitis C Virus (HCV) Direct-Acting Antiviral Therapy in Persons With Human Immunodeficiency Virus–HCV Genotype 1 Coinfection Resulting in High Rate of Sustained Virologic Response and Variable in Normalization of Soluble Markers of Immune Activation","abstract":"BACKGROUND: Hepatitis C virus (HCV) direct-acting antivirals are highly effective. Less is known about changes in markers of immune activation in persons with human immunodeficiency virus (HIV) in whom a sustained virologic response (SVR) is achieved. METHODS: We conducted a nonrandomized clinical trial of 12 or 24 weeks of paritaprevir-ritonavir-ombitasvir plus dasabuvir (PrOD) with or without ribavirin in persons with HCV-1/HIV coinfection suppressed with antiretroviral therapy. Plasma HCV, soluble CD14 (sCD14), interferon-inducible protein 10, soluble CD163 (sCD163), interleukin 6 (IL-6), interleukin 18, monocyte chemoattractant protein (MCP-1), autotaxin (ATX), and Mac2-binding protein (Mac2BP) were measured over 48 weeks. RESULTS: Participants were treated with PrOD for 12 (n = 9) or 24 (n = 36) weeks; the SVR rate at 12 weeks was 93%. At baseline, cirrhosis was associated with higher ATX and MCP-1, female sex with higher ATX and IL-6, older age with higher Mac2BP, higher body mass index with higher ATX, and HIV-1 protease inhibitor use with higher sCD14 levels. In those with SVR, interferon-inducible protein 10, ATX, and Mac2BP levels declined by week 2, interleukin 18 levels declined by the end of treatment, sCD14 levels did not change, and sCD163, MCP-1, and IL-6 levels changed at a single time point. CONCLUSIONS: During HIV/HCV coinfection, plasma immune activation marker heterogeneity is in part attributable to age, sex, cirrhosis, body mass index, and/or type of antiretroviral therapy. HCV treatment with paritaprevir-ritonavir-ombitasvir plus dasabuvir is highly effective and is associated with variable rate and magnitude of decline in markers of immune activation. CLINICAL TRIALS REGISTRATION: NCT02194998.","journal":"The Journal of Infectious Diseases","year":2020,"id":86885,"datarank":0.49653518310647204,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.11179277948724146,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.11179277948724146,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02194998"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315359,"name":"Mark Sulkowski","orcid":"0000-0002-2145-6352","position":1,"is_corresponding":false},{"id":434569,"name":"Laura Smeaton","orcid":"0000-0001-7243-4703","position":2,"is_corresponding":false},{"id":442328,"name":"Sofi Damjanovska","orcid":"0000-0001-6036-9190","position":3,"is_corresponding":false},{"id":333572,"name":"Carey L. Shive","orcid":"0000-0002-6908-1246","position":4,"is_corresponding":false},{"id":443034,"name":"Corinne Kowal","orcid":null,"position":5,"is_corresponding":false},{"id":434572,"name":"Daniel E. Cohen","orcid":"0000-0002-7911-227X","position":6,"is_corresponding":false},{"id":442329,"name":"Debika Bhattacharya","orcid":"0000-0002-2136-7763","position":7,"is_corresponding":false},{"id":435245,"name":"Beverly Alston‐Smith","orcid":null,"position":8,"is_corresponding":false},{"id":434568,"name":"Ashwin Balagopal","orcid":"0000-0002-6143-3104","position":9,"is_corresponding":false},{"id":414478,"name":"David Wyles","orcid":"0009-0000-3750-5924","position":10,"is_corresponding":false},{"id":434574,"name":"Donald D. Anthony","orcid":"0000-0002-1226-5976","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32406487","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}