{"doi":"10.1093/infdis/jiaa250","title":"Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion","abstract":"Deletion of the pfhrp2 gene in Plasmodium falciparum can lead to false-negative rapid diagnostic test (RDT) results, constituting a major challenge for evidence-based malaria treatment. Here we analyzed the whole genome sequences of 138 P. falciparum clinical samples collected from the China-Myanmar boarder for pfhrp2 and pfhrp3 gene deletions. We found pfhrp2 and pfhrp3 deletions in 9.4% and 3.6% of samples, respectively, with no samples harboring deletions of both genes. The pfhrp2 deletions showed 2 distinct breakpoints, representing 2 different chromosomal deletion events. A phylogenetic analysis performed using genome-wide single-nucleotide polymorphisms revealed that the 2 pfhrp2 breakpoint groups as well as all the pfhrp3-negative parasites formed separate clades, suggesting they might have resulted from clonal expansion of pfhrp2- and pfhrp3-negative parasites. These findings highlight the need for urgent surveys to determine the prevalence of pfhrp2-negative parasites causing false-negative RDT results and a plan for switching of RDTs pending the survey results.","journal":"The Journal of Infectious Diseases","year":2020,"id":80210,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9384,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417054,"name":"Junling Qin","orcid":null,"position":1,"is_corresponding":false},{"id":415515,"name":"Pallavi Malla","orcid":"0000-0002-2312-7720","position":2,"is_corresponding":false},{"id":417055,"name":"Zenglei Wang","orcid":null,"position":3,"is_corresponding":false},{"id":416032,"name":"Awtum Brashear","orcid":"0000-0001-9206-0737","position":4,"is_corresponding":false},{"id":416033,"name":"Chengqi Wang","orcid":"0000-0002-7582-3824","position":5,"is_corresponding":false},{"id":316528,"name":"Jun Miao","orcid":"0000-0001-9374-6749","position":6,"is_corresponding":false},{"id":398225,"name":"John H. Adams","orcid":"0000-0003-3707-7979","position":7,"is_corresponding":false},{"id":406378,"name":"Kami Kim","orcid":"0000-0003-3384-152X","position":8,"is_corresponding":false},{"id":416034,"name":"Rays H. Y. Jiang","orcid":"0000-0001-8982-4169","position":9,"is_corresponding":false},{"id":308914,"name":"Liwang Cui","orcid":"0000-0002-8338-1974","position":10,"is_corresponding":false},{"id":416031,"name":"Justin Gibbons","orcid":"0000-0001-7156-6704","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T21:51:24.704381Z","pmid":"32386321","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}