{"doi":"10.1093/infdis/jiaa249","title":"Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE","abstract":"BACKGROUND: People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with physical function impairment and frailty can help target interventions. METHODS: The REPRIEVE trial enrolled participants 40-75 years of age, receiving stable antiretroviral therapy with CD4+ T-cell count >100 cells/mm3, and with low to moderate cardiovascular disease risk. We conducted a cross-sectional analysis of those concurrently enrolled in the ancillary study PREPARE at enrollment. RESULTS: Among the 266 participants, the median age was 51 years; 81% were male, and 45% were black, and 28% had hypertension. Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) was 25 to <30 in 38% and ≥30 in 30%, 33% had a high waist circumference, 89% were physically inactive, 37% (95% confidence interval, 31%, 43%) had physical function impairment (Short Physical Performance Battery score ≤10), and 6% (4%, 9%) were frail and 42% prefrail. In the adjusted analyses, older age, black race, greater BMI, and physical inactivity were associated with physical function impairment; depression and hypertension were associated with frailty or prefrailty. CONCLUSIONS: Physical function impairment was common among middle-aged PWH; greater BMI and physical inactivity are important modifiable factors that may prevent further decline in physical function with aging. CLINICAL TRIALS REGISTRATION: NCT02344290.","journal":"The Journal of Infectious Diseases","year":2020,"id":95967,"datarank":1.1547088225734976,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.617180981805081,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.617180981805081,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":23,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8608,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02344290"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109430,"name":"Todd T. Brown","orcid":"0000-0001-8599-278X","position":1,"is_corresponding":false},{"id":437399,"name":"Edgar T. Overton","orcid":"0000-0002-4013-536X","position":2,"is_corresponding":false},{"id":396977,"name":"Heather J. Ribaudo","orcid":"0000-0002-0394-3990","position":3,"is_corresponding":false},{"id":264188,"name":"Jennifer A. Schrack","orcid":"0000-0001-9244-9267","position":4,"is_corresponding":false},{"id":381594,"name":"Kathleen V. Fitch","orcid":"0000-0002-0541-3707","position":5,"is_corresponding":false},{"id":282488,"name":"Pamela S. Douglas","orcid":"0000-0001-9876-4049","position":6,"is_corresponding":false},{"id":12007,"name":"Steven Grinspoon","orcid":"0000-0002-6338-000X","position":7,"is_corresponding":false},{"id":477852,"name":"Sarah Henn","orcid":null,"position":8,"is_corresponding":false},{"id":279024,"name":"Roberto C. Arduino","orcid":"0000-0002-7381-844X","position":9,"is_corresponding":false},{"id":333576,"name":"Benigno Rodríguez","orcid":"0000-0001-9736-7957","position":10,"is_corresponding":false},{"id":294607,"name":"Constance A. Benson","orcid":"0000-0002-3781-1347","position":11,"is_corresponding":false},{"id":242505,"name":"Kristine M. Erlandson","orcid":"0000-0003-0808-6729","position":12,"is_corresponding":false},{"id":476483,"name":"Triin Umbleja","orcid":"0000-0001-7161-7743","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32645163","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}