{"doi":"10.1093/infdis/jiaa127","title":"The Application of Cytokine Expression Assays to Differentiate Active From Previously Treated Syphilis","abstract":"To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, brain-derived neurotrophic factor and tumor necrosis factor β, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95% confidence interval, 82%-100%) sensitive, and 45% (18%-75%) specific. Our decision tree differentiated between serum specimens from serofast participants with treated syphilis versus active syphilis.","journal":"The Journal of Infectious Diseases","year":2020,"id":107139,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":515952,"name":"Janet Siebert","orcid":"0000-0001-8505-9359","position":1,"is_corresponding":false},{"id":3342,"name":"Holden T. Maecker","orcid":"0000-0003-0795-9946","position":2,"is_corresponding":false},{"id":13000,"name":"Yael Rosenberg‐Hasson","orcid":"0000-0002-3284-5732","position":3,"is_corresponding":false},{"id":499365,"name":"Segundo R. León","orcid":"0000-0002-5630-5714","position":4,"is_corresponding":false},{"id":382533,"name":"Silver K. Vargas","orcid":"0000-0002-8188-9598","position":5,"is_corresponding":false},{"id":382532,"name":"Kelika A. Konda","orcid":"0000-0003-2836-0174","position":6,"is_corresponding":false},{"id":382538,"name":"Carlos F. Cáceres","orcid":"0000-0002-8101-0790","position":7,"is_corresponding":false},{"id":250389,"name":"Jeffrey D. Klausner","orcid":"0000-0002-6922-7364","position":8,"is_corresponding":false},{"id":250387,"name":"Noah Kojima","orcid":"0000-0002-3667-9719","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-18T23:12:34.898963Z","pmid":"32189000","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}