{"doi":"10.1093/infdis/jiaa126","title":"Intrahepatic Viral Kinetics During Direct-Acting Antivirals for Hepatitis C in Human Immunodeficiency Virus Coinfection: The AIDS Clinical Trials Group A5335S Substudy","abstract":"BACKGROUND: Direct-acting antivirals (DAAs) targeting hepatitis C virus (HCV) have revolutionized outcomes in human immunodeficiency virus (HIV) coinfection. METHODS: We examined early events in liver and plasma through A5335S, a substudy of trial A5329 (paritaprevir/ritonavir, ombitasvir, dasabuvir, with ribavirin) that enrolled chronic genotype 1a HCV-infected persons coinfected with suppressed HIV: 5 of 6 treatment-naive enrollees completed A5335S. RESULTS: Mean baseline plasma HCV ribonucleic acid (RNA) = 6.7 log10 IU/mL and changed by -4.1 log10 IU/mL by Day 7. In liver, laser capture microdissection was used to quantify HCV. At liver biopsy 1, mean %HCV-infected cells = 25.2% (95% confidence interval [CI], 7.4%-42.9%), correlating with plasma HCV RNA (Spearman rank correlation r = 0.9); at biopsy 2 (Day 7 in 4 of 5 participants), mean %HCV-infected cells = 1.0% (95% CI, 0.2%-1.7%) (P < .05 for change), and DAAs were detectable in liver. Plasma C-X-C motif chemokine 10 (CXCL10) concentrations changed by mean = -160 pg/mL per day at 24 hours, but no further after Day 4. CONCLUSIONS: We conclude that HCV infection is rapidly cleared from liver with DAA leaving <2% HCV-infected hepatocytes at Day 7. We extrapolate that HCV eradication could occur in these participants by 63 days, although immune activation might persist. Single-cell longitudinal estimates of HCV clearance from liver have never been reported previously and could be applied to estimating the minimum treatment duration required for HCV infection.","journal":"The Journal of Infectious Diseases","year":2020,"id":84877,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9403,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":434569,"name":"Laura Smeaton","orcid":"0000-0001-7243-4703","position":1,"is_corresponding":false},{"id":434570,"name":"Jeffrey Quinn","orcid":"0000-0002-4734-5108","position":2,"is_corresponding":false},{"id":434571,"name":"Charles S. Venuto","orcid":"0000-0002-2394-9513","position":3,"is_corresponding":false},{"id":258962,"name":"Gene D. Morse","orcid":"0000-0001-6758-0941","position":4,"is_corresponding":false},{"id":435244,"name":"Vincent Vu","orcid":null,"position":5,"is_corresponding":false},{"id":435245,"name":"Beverly Alston‐Smith","orcid":null,"position":6,"is_corresponding":false},{"id":434572,"name":"Daniel E. Cohen","orcid":"0000-0002-7911-227X","position":7,"is_corresponding":false},{"id":434573,"name":"Jorge Santana‐Bagur","orcid":"0000-0003-2822-3401","position":8,"is_corresponding":false},{"id":434574,"name":"Donald D. Anthony","orcid":"0000-0002-1226-5976","position":9,"is_corresponding":false},{"id":315359,"name":"Mark Sulkowski","orcid":"0000-0002-2145-6352","position":10,"is_corresponding":false},{"id":414478,"name":"David Wyles","orcid":"0009-0000-3750-5924","position":11,"is_corresponding":false},{"id":434575,"name":"Andrew H. Talal","orcid":"0000-0002-5565-7515","position":12,"is_corresponding":false},{"id":434568,"name":"Ashwin Balagopal","orcid":"0000-0002-6143-3104","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T21:55:38.506333Z","pmid":"32201883","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}