{"doi":"10.1093/infdis/jiaa026","title":"Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2","abstract":"BACKGROUND: HIV-1 and HIV-2 differ in their antiretroviral (ARV) susceptibilities and drug resistance mutations (DRMs). METHODS: We analyzed published HIV-2 pol sequences to identify HIV-2 treatment-selected mutations (TSMs). Mutation prevalences were determined by HIV-2 group and ARV status. Nonpolymorphic mutations were those in <1% of ARV-naive persons. TSMs were those associated with ARV therapy after multiple comparisons adjustment. RESULTS: We analyzed protease (PR) sequences from 483 PR inhibitor (PI)-naive and 232 PI-treated persons; RT sequences from 333 nucleoside RT inhibitor (NRTI)-naive and 252 NRTI-treated persons; and integrase (IN) sequences from 236 IN inhibitor (INSTI)-naive and 60 INSTI-treated persons. In PR, 12 nonpolymorphic TSMs occurred in ≥11 persons: V33I, K45R, V47A, I50V, I54M, T56V, V62A, A73G, I82F, I84V, F85L, L90M. In RT, 9 nonpolymorphic TSMs occurred in ≥10 persons: K40R, A62V, K70R, Y115F, Q151M, M184VI, S215Y. In IN, 11 nonpolymorphic TSMs occurred in ≥4 persons: Q91R, E92AQ, T97A, G140S, Y143G, Q148R, A153G, N155H, H156R, R231 5-amino acid insertions. Nine of 32 nonpolymorphic TSMs were previously unreported. CONCLUSIONS: This meta-analysis confirmed the ARV association of previously reported HIV-2 DRMs and identified novel TSMs. Genotypic and phenotypic studies of HIV-2 TSMs will improve approaches to predicting HIV-2 ARV susceptibility and treating HIV-2-infected persons.","journal":"The Journal of Infectious Diseases","year":2020,"id":102069,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":36848,"name":"Diane Descamps","orcid":"0000-0002-6556-1525","position":1,"is_corresponding":false},{"id":14782,"name":"Soo‐Yon Rhee","orcid":"0000-0002-1231-6542","position":2,"is_corresponding":false},{"id":391187,"name":"Dana N. Raugi","orcid":"0000-0001-6205-845X","position":3,"is_corresponding":false},{"id":69656,"name":"Charlotte Charpentier","orcid":"0000-0002-6441-7054","position":4,"is_corresponding":false},{"id":48733,"name":"Nuno Taveira","orcid":"0000-0003-0176-5585","position":5,"is_corresponding":false},{"id":391189,"name":"Robert A. Smith","orcid":"0000-0003-3202-1650","position":6,"is_corresponding":false},{"id":500059,"name":"Vicente Soriano","orcid":null,"position":7,"is_corresponding":false},{"id":499025,"name":"Carmen de Mendoza","orcid":"0000-0001-5224-7492","position":8,"is_corresponding":false},{"id":31864,"name":"Susan Holmes","orcid":"0000-0002-2208-8168","position":9,"is_corresponding":false},{"id":391190,"name":"Geoffrey S. Gottlieb","orcid":"0000-0002-5749-481X","position":10,"is_corresponding":false},{"id":14780,"name":"Robert W. Shafer","orcid":"0000-0003-2513-2643","position":11,"is_corresponding":false},{"id":97198,"name":"Philip L. Tzou","orcid":"0000-0002-2876-1552","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T22:40:51.552773Z","pmid":"31965175","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}