{"doi":"10.1093/immhor/vlaf045","title":"CD4 and CD8 T-cell response is dominated by IL-10–secreting cells in children with uncomplicated <i>Plasmodium falciparum</i> malaria","abstract":"Plasmodium falciparum malaria and Epstein-Barr virus (EBV) coinfections have been associated with an increased risk of developing the EBV-associated cancer endemic Burkitt lymphoma (eBL). In children living in malaria-endemic areas, repeated episodes of malaria may alter the immune system's ability to suppress EBV, creating a permissive environment for eBL pathogenesis. However, the malaria-driven mechanisms involved remain undefined, including whether malaria-induced immune alterations are EBV-specific or systemic. To identify whether acute clinical P. falciparum malaria affects EBV T-cell immunity, we characterized T-cell activation status and cytokine secretion profiles using flow cytometry. We compared profiles in 10 Kenyan children with acute clinical P. falciparum malaria at baseline and matched 4-week recovery, and 10 healthy community controls following antigenic stimulation with EBV- and cytomegalovirus-specific peptides. The percentage frequency of activation-induced marker cells was comparable within the study cohort across the different stimulations. Furthermore, we observed a shift in cytokine secretion in children with acute malaria during active disease and at 4 weeks postrecovery, favoring IL-10 for both T-cell subsets. Our findings suggest that clinical malaria did not result in the impairment of T-cell activation, but rather induced shifts in cytokine secretion in favor of IL-10. We further demonstrate that malaria-induced T-cell immune alterations are not EBV-specific but rather affect overall immune suppression.","journal":"ImmunoHorizons","year":2025,"id":548857,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342435,"name":"Bernard Guyah","orcid":"0000-0002-9936-9996","position":1,"is_corresponding":false},{"id":1443031,"name":"Ian Onditi","orcid":null,"position":2,"is_corresponding":false},{"id":1411471,"name":"Kevin Waomba","orcid":"0009-0000-3410-0198","position":3,"is_corresponding":false},{"id":1324179,"name":"Emily Koech","orcid":"0000-0001-9481-9540","position":4,"is_corresponding":false},{"id":504572,"name":"Katherine R. Sabourin","orcid":"0000-0002-6147-9196","position":5,"is_corresponding":false},{"id":796273,"name":"Gabriela Samayoa-Reyes","orcid":"0000-0001-7614-9600","position":6,"is_corresponding":false},{"id":504575,"name":"Rosemary Rochford","orcid":"0000-0002-0001-5152","position":7,"is_corresponding":false},{"id":504574,"name":"Sidney Ogolla","orcid":"0000-0003-1570-6164","position":8,"is_corresponding":false},{"id":1191447,"name":"Bonface Ariera","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:54:03.053965Z","pmid":"41285032","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}