{"doi":"10.1093/ije/dyl003","title":"Commentary: Grading the credibility of molecular evidence for complex diseases","abstract":"Dissecting the aetiology of complex diseases has been a great challenge for biomedical research, including epidemiology. Several thinkers, 1–4 including Buchanan et al. 5 recently, have focused on the unquestionable difficulties of this ambitious enterprise and the great obstacles encountered in the way. Some of them have ended up with a futility outlook. Over more than a decade, the debate has ranged wild on whether epidemiology has reached its limits, 6 is either dead or in a vegetative state, should call it a day, and whether ‘it is time for scientists to re-think the quest’ and realize that ‘base metal cannot be turned to gold’. 5","journal":"International Journal of Epidemiology","year":2006,"id":8634,"datarank":0.6064576901751826,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":0.0,"self_endowment_contribution":0.6064576901751826,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0441,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2006-03-15","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}