{"doi":"10.1093/ije/dyae059","title":"Dietary intake of copper and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project","abstract":"BACKGROUND: Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC. METHODS: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. RESULTS: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes. CONCLUSIONS: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.","journal":"International Journal of Epidemiology","year":2024,"id":460921,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7695,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":669267,"name":"Giulia Collatuzzo","orcid":"0000-0002-2309-7365","position":1,"is_corresponding":false},{"id":1289032,"name":"Monireh Sadat Seyyedsalehi","orcid":"0000-0002-9063-9128","position":2,"is_corresponding":false},{"id":321663,"name":"Claudio Pelucchi","orcid":"0000-0003-1425-8945","position":3,"is_corresponding":false},{"id":321667,"name":"Rossella Bonzi","orcid":"0000-0002-2155-6126","position":4,"is_corresponding":false},{"id":39038,"name":"Domenico Palli","orcid":"0000-0002-5558-2437","position":5,"is_corresponding":false},{"id":321665,"name":"Monica Ferraroni","orcid":"0000-0002-4542-4996","position":6,"is_corresponding":false},{"id":38884,"name":"Nuno Lunet","orcid":"0000-0003-1870-1430","position":7,"is_corresponding":false},{"id":321660,"name":"Samantha Morais","orcid":"0000-0001-5808-0179","position":8,"is_corresponding":false},{"id":321669,"name":"Lizbeth López‐Carrillo","orcid":"0000-0002-3245-8337","position":9,"is_corresponding":false},{"id":275792,"name":"Reza Malekzadeh","orcid":"0000-0002-9820-6335","position":10,"is_corresponding":false},{"id":321673,"name":"Mohammadreza Pakseresht","orcid":"0000-0003-1356-9135","position":11,"is_corresponding":false},{"id":96862,"name":"Malaquı́as López-Cervantes","orcid":"0000-0001-9936-8427","position":12,"is_corresponding":false},{"id":282614,"name":"Mary H. 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Constanza Camargo","orcid":"0000-0002-1065-2198","position":14,"is_corresponding":false},{"id":265952,"name":"María Paula Curado","orcid":"0000-0001-8172-2483","position":15,"is_corresponding":false},{"id":39598,"name":"Jesús Vioqué","orcid":"0000-0002-2284-148X","position":16,"is_corresponding":false},{"id":265958,"name":"Zuo‐Feng Zhang","orcid":"0000-0002-4669-3995","position":17,"is_corresponding":false},{"id":3357,"name":"Stefania Boccia","orcid":"0000-0002-1864-749X","position":18,"is_corresponding":false},{"id":45022,"name":"Eva Negri","orcid":"0000-0001-9712-8526","position":19,"is_corresponding":false},{"id":5906,"name":"Carlo La Vecchia","orcid":"0000-0003-1441-897X","position":20,"is_corresponding":false},{"id":265963,"name":"Paolo Boffetta","orcid":"0000-0002-3811-2791","position":21,"is_corresponding":false},{"id":1289031,"name":"Michele Sassano","orcid":"0000-0002-3158-1827","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:04:07.925246Z","pmid":"38670544","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}