{"doi":"10.1093/ije/dyac030","title":"Pre-trauma predictors of severe psychiatric comorbidity 5 years following traumatic experiences","abstract":"BACKGROUND: A minority of persons who have traumatic experiences go on to develop post-traumatic stress disorder (PTSD), leading to interest in who is at risk for psychopathology after these experiences. Complicating this effort is the observation that post-traumatic psychopathology is heterogeneous. The goal of this nested case-control study was to identify pre-trauma predictors of severe post-traumatic psychiatric comorbidity, using data from Danish registries. METHODS: The source population for this study was the population of Denmark from 1994 through 2016. Cases had received three or more psychiatric diagnoses (across all ICD-10 categories) within 5 years of a traumatic experience (n = 20 361); controls were sampled from the parent cohort using risk-set sampling (n = 81 444). Analyses were repeated in samples stratified by pre-trauma psychiatric diagnoses. We used machine learning methods (classification and regression trees and random forest) to determine the important predictors of severe post-trauma psychiatric comorbidity from among hundreds of pre-trauma predictor variables spanning demographic and social variables, psychiatric and somatic diagnoses and filled medication prescriptions. RESULTS: In the full sample, pre-trauma psychiatric diagnoses (e.g. stress disorders, alcohol-related disorders, personality disorders) were the most important predictors of severe post-trauma psychiatric comorbidity. Among persons with no pre-trauma psychiatric diagnoses, demographic and social variables (e.g. marital status), type of trauma, medications used primarily to treat psychiatric symptomatology, anti-inflammatory medications and gastrointestinal distress were important to prediction. Results among persons with pre-trauma psychiatric diagnoses were consistent with the overall sample. CONCLUSIONS: This study builds on the understanding of pre-trauma factors that predict psychopathology following traumatic experiences, by examining a broad range of predictors of post-trauma psychopathology and comorbidity beyond PTSD.","journal":"International Journal of Epidemiology","year":2022,"id":257181,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":907070,"name":"Anthony J. Rosellini","orcid":"0000-0002-8385-8621","position":1,"is_corresponding":false},{"id":877666,"name":"Péter Szentkúti","orcid":"0000-0002-7831-999X","position":2,"is_corresponding":false},{"id":355538,"name":"Erzsébet Horváth–Puhó","orcid":"0000-0002-3594-2212","position":3,"is_corresponding":false},{"id":488306,"name":"Meghan L. Smith","orcid":"0000-0003-0444-2845","position":4,"is_corresponding":false},{"id":673604,"name":"Isaac R. Galatzer‐Levy","orcid":"0000-0003-1864-064X","position":5,"is_corresponding":false},{"id":387406,"name":"Timothy L. Lash","orcid":"0000-0002-5240-5195","position":6,"is_corresponding":false},{"id":104700,"name":"Sandro Galea","orcid":"0000-0002-7534-0945","position":7,"is_corresponding":false},{"id":529087,"name":"Paula P. Schnurr","orcid":"0000-0002-6195-716X","position":8,"is_corresponding":false},{"id":236234,"name":"Henrik Toft Sørensen","orcid":"0000-0003-4299-7040","position":9,"is_corresponding":false},{"id":525332,"name":"Jaimie L. Gradus","orcid":"0000-0003-1459-5327","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:25:30.183987Z","pmid":"35179599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}