{"doi":"10.1093/ije/dyaa017","title":"Association between the pregnancy exposome and fetal growth","abstract":"BACKGROUND: Several environmental contaminants were shown to possibly influence fetal growth, generally from single exposure family studies, which are prone to publication bias and confounding by co-exposures. The exposome paradigm offers perspectives to avoid selective reporting of findings and to control for confounding by co-exposures. We aimed to characterize associations of fetal growth with the pregnancy chemical and external exposomes. METHODS: Within the Human Early-Life Exposome project, 131 prenatal exposures were assessed using biomarkers and environmental models in 1287 mother-child pairs from six European cohorts. We investigated their associations with fetal growth using a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering each exposure independently. We corrected for exposure measurement error and tested for exposure-exposure and sex-exposure interactions. RESULTS: The DSA model identified lead blood level, which was associated with a 97 g birth weight decrease for each doubling in lead concentration. No exposure passed the multiple testing-corrected significance threshold of ExWAS; without multiple testing correction, this model was in favour of negative associations of lead, fine particulate matter concentration and absorbance with birth weight, and of a positive sex-specific association of parabens with birth weight in boys. No two-way interaction between exposure variables was identified. CONCLUSIONS: This first large-scale exposome study of fetal growth simultaneously considered >100 environmental exposures. Compared with single exposure studies, our approach allowed making all tests (usually reported in successive publications) explicit. Lead exposure is still a health concern in Europe and parabens health effects warrant further investigation.","journal":"International Journal of Epidemiology","year":2020,"id":93661,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237212,"name":"Xavier Basagaña","orcid":"0000-0002-8457-1489","position":1,"is_corresponding":false},{"id":467552,"name":"Carles Hernandéz-Ferrer","orcid":"0000-0002-8029-7160","position":2,"is_corresponding":false},{"id":237187,"name":"Léa Maître","orcid":"0000-0003-3682-7117","position":3,"is_corresponding":false},{"id":237205,"name":"Ibón Tamayo","orcid":"0000-0002-8183-7106","position":4,"is_corresponding":false},{"id":237206,"name":"José Urquiza","orcid":"0000-0003-2220-607X","position":5,"is_corresponding":false},{"id":237191,"name":"Sandra Andrušaitytė","orcid":"0000-0002-4309-0208","position":6,"is_corresponding":false},{"id":237193,"name":"Maribel Casas","orcid":"0000-0002-2112-6740","position":7,"is_corresponding":false},{"id":237194,"name":"Montserrat de Castro","orcid":"0000-0001-6547-5953","position":8,"is_corresponding":false},{"id":467553,"name":"Enrique Cequier","orcid":"0000-0002-0023-3870","position":9,"is_corresponding":false},{"id":239089,"name":"Leda Chatzi","orcid":null,"position":10,"is_corresponding":false},{"id":237196,"name":"David Donaire-González","orcid":"0000-0003-2337-1712","position":11,"is_corresponding":false},{"id":467554,"name":"Lise Giorgis-Allemand","orcid":"0000-0002-5721-7046","position":12,"is_corresponding":false},{"id":257614,"name":"Juan R. 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