{"doi":"10.1093/ibd/izae250","title":"GLP-1 Receptor Agonists Confer No Increased Rates of IBD Exacerbation Among Patients With IBD","abstract":"BACKGROUND: In patients with inflammatory bowel disease (IBD), multimorbidity with obesity and type 2 diabetes is common and increasing. Glucagon-like peptide 1 (GLP-1) receptor agonists are increasingly being prescribed for patients with IBD, yet their impact on patients with IBD is largely unknown. We aimed to assess the impact of GLP-1 receptor agonists on the course of IBD. METHODS: We identified all IBD patients prescribed GLP-1 receptor agonists at a large academic healthcare network between 2009 and 2023. We analyzed demographics and IBD characteristics in the year pre- and post-GLP-1 receptor agonist prescription and matched them to non-IBD controls. Our primary outcome was IBD exacerbation in the year following GLP-1 receptor agonist initiation, measured as a composite of IBD-related hospitalization, corticosteroid prescription, medication escalation or changes, or IBD-related surgery. Secondary outcomes included change in metabolic risk factors. RESULTS: Overall, 224 patients met inclusion criteria. At GLP-1 receptor agonist initiation, the median age was 54 years, 63% were female, 77% were White, and median BMI was 33.2 kg/m2. Compared to the 12-month period prior to GLP-1 receptor agonist initiation, in the 12 months post-GLP-1 receptor agonist initiation, there was no change in rates of IBD exacerbation, IBD-related hospitalization, steroids prescription, medication escalation or changes, or IBD-related surgery. There was a significant decrease in BMI in the year following GLP-1 receptor agonist initiation (median BMI 33.5 vs 31.6 kg/m2, P < .01), with rates of decrease comparable to non-IBD matched controls. CONCLUSIONS: In patients with IBD, GLP-1 receptor agonists are effective for weight loss and associated with few episodes of disease exacerbation.","journal":"Inflammatory Bowel Diseases","year":2024,"id":423116,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1218142,"name":"Shaina Sekhri","orcid":"0000-0001-8691-9955","position":1,"is_corresponding":false},{"id":721054,"name":"William Schreiber-Stainthorp","orcid":"0000-0002-7386-8754","position":2,"is_corresponding":false},{"id":1218791,"name":"Brandon Locke","orcid":null,"position":3,"is_corresponding":false},{"id":1218792,"name":"Olivia Delau","orcid":null,"position":4,"is_corresponding":false},{"id":1218793,"name":"M. F. S. El-Hawary","orcid":null,"position":5,"is_corresponding":false},{"id":1104752,"name":"Krutika Pandit","orcid":null,"position":6,"is_corresponding":false},{"id":1218794,"name":"Xucong Meng","orcid":null,"position":7,"is_corresponding":false},{"id":345072,"name":"Jordan E. Axelrad","orcid":"0000-0003-1951-7790","position":8,"is_corresponding":false},{"id":1218141,"name":"Irving Levine","orcid":"0000-0003-4922-1835","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:57:56.814994Z","pmid":"39438251","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}