{"doi":"10.1093/ibd/izaa283","title":"Inflammatory Bowel Disease Outcomes Following Fecal Microbiota Transplantation for Recurrent <i>C. difficile</i> Infection","abstract":"BACKGROUND: Recurrent Clostridioides difficile infection (CDI) in patients with inflammatory bowel disease (IBD) is a clinical challenge. Fecal microbiota transplantation (FMT) has emerged as a recurrent CDI therapy. Anecdotal concerns exist regarding worsening of IBD activity; however, prospective data among IBD patients are limited. METHODS: Secondary analysis from an open-label, prospective, multicenter cohort study among IBD patients with 2 or more CDI episodes was performed. Participants underwent a single FMT by colonoscopy (250 mL, healthy universal donor). Secondary IBD-related outcomes included rate of de novo IBD flares, worsening IBD, and IBD improvement-all based on Mayo or Harvey-Bradshaw index (HBI) scores. Stool samples were collected for microbiome and targeted metabolomic profiling. RESULTS: Fifty patients enrolled in the study, among which 15 had Crohn's disease (mean HBI, 5.8 ± 3.4) and 35 had ulcerative colitis (mean partial Mayo score, 4.2 ± 2.1). Overall, 49 patients received treatment. Among the Crohn's disease cohort, 73.3% (11 of 15) had IBD improvement, and 4 (26.6%) had no disease activity change. Among the ulcerative colitis cohort, 62% (22 of 34) had IBD improvement, 29.4% (11 of 34) had no change, and 4% (1 of 34) experienced a de novo flare. Alpha diversity significantly increased post-FMT, and ulcerative colitis patients became more similar to the donor than Crohn's disease patients (P = 0.04). CONCLUSION: This prospective trial assessing FMT in IBD-CDI patients suggests IBD outcomes are better than reported in retrospective studies.","journal":"Inflammatory Bowel Diseases","year":2020,"id":62165,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9406,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245334,"name":"Colleen Kelly","orcid":"0000-0003-2996-747X","position":1,"is_corresponding":false},{"id":245336,"name":"Ari Grinspan","orcid":"0000-0002-0719-1538","position":2,"is_corresponding":false},{"id":328806,"name":"Benjamin H. 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Alexander","orcid":"0000-0001-8542-327X","position":14,"is_corresponding":false},{"id":328811,"name":"Kate Gallagher","orcid":"0000-0003-2615-3112","position":15,"is_corresponding":false},{"id":330217,"name":"Will Pettee","orcid":null,"position":16,"is_corresponding":false},{"id":322090,"name":"Emmalee Phelps","orcid":null,"position":17,"is_corresponding":false},{"id":328812,"name":"Sára Nemes","orcid":"0000-0003-1483-3719","position":18,"is_corresponding":false},{"id":328813,"name":"Sashidhar Sagi","orcid":"0000-0002-5794-7030","position":19,"is_corresponding":false},{"id":320934,"name":"Matthew Bohm","orcid":"0000-0002-5155-3807","position":20,"is_corresponding":false},{"id":328814,"name":"Zain Kassam","orcid":"0000-0002-2183-2223","position":21,"is_corresponding":false},{"id":245345,"name":"Monika Fischer","orcid":"0000-0001-7162-6172","position":22,"is_corresponding":false},{"id":218583,"name":"Jessica R. 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