{"doi":"10.1093/ibd/izaa220","title":"Clinical Variables Associated With Statural Growth in Pediatric Crohn’s Disease Differ by Sex (The Growth Study)","abstract":"BACKGROUND: Statural growth impairment is more common in male patients with Crohn's disease (CD). We identified clinical variables associated with height z score differences by sex in children participating in the Growth Study, a prospective multicenter longitudinal study examining sex differences in growth impairment in pediatric CD. METHODS: Patients with CD (female patients with bone age [BA] ≥4 years 2 months and ≤12 years; male patients with BA ≥5 years and ≤14 years at screening) who had completed study visit 1 qualified. The height z score difference was computed as height z score based on chronological age minus height z score based on BA. RESULTS: One hundred thirteen patients with CD (36% female) qualified. The mean chronological age was 12.0 ± 1.8 (SD) years. The magnitude of the mean height z score difference was significantly greater in female patients (-0.9 ± 0.8) than in male patients (-0.5 ± 0.9; P = 0.021). An initial classification of inflammatory bowel disease as CD (P = 0.038) and perianal disease behavior at diagnosis (P = 0.009) were associated with higher standardized height gain with BA progression, and arthralgia at symptom onset (P = 0.016), azathioprine/6-merpcaptopurine (P = 0.041), and probiotics (P ≤ 0.021) were associated with lower standardized height gain with BA progression in female patients. Patient-reported poor growth at symptom onset (P = 0.001), infliximab (P ≤ 0.025), biologics (P ≤ 0.015), methotrexate (P = 0.042), and vitamin D (P ≤ 0.010) were associated with higher standardized height gain with BA progression, and initial classification as CD (P = 0.025) and anorexia (P = 0.005) or mouth sores (P = 0.004) at symptom onset were associated with lower standardized height gain with BA progression in male patients. CONCLUSIONS: Different clinical variables were associated with statural growth in male patients vs female patients, suggesting that sex-specific molecular pathways lead to statural growth impairment in CD.","journal":"Inflammatory Bowel Diseases","year":2020,"id":74728,"datarank":0.42888975738754764,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0993060707871147,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0993060707871147,"corpus_percentile":56.58698847373714,"corpus_rank":5613,"citation_count":8,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6204,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390710,"name":"Robert H. Lustig","orcid":"0000-0001-6983-2639","position":1,"is_corresponding":false},{"id":268366,"name":"Howard Andrews","orcid":"0000-0002-7726-0551","position":2,"is_corresponding":false},{"id":390711,"name":"Ranjana Gokhale","orcid":"0000-0002-2632-8253","position":3,"is_corresponding":false},{"id":390712,"name":"Alka Goyal","orcid":"0000-0002-9605-3734","position":4,"is_corresponding":false},{"id":390713,"name":"Ashish Patel","orcid":"0000-0002-4435-2644","position":5,"is_corresponding":false},{"id":296199,"name":"Stephen L. Guthery","orcid":"0000-0003-1484-301X","position":6,"is_corresponding":false},{"id":339583,"name":"Francisco Sylvester","orcid":"0000-0001-7522-8956","position":7,"is_corresponding":false},{"id":391660,"name":"Leah Siebold","orcid":null,"position":8,"is_corresponding":false},{"id":390714,"name":"Cheng‐Shiun Leu","orcid":"0000-0002-0301-8316","position":9,"is_corresponding":false},{"id":390709,"name":"Neera Gupta","orcid":"0000-0002-4981-7463","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:46:11.663457Z","pmid":"32860033","pmcid":"PMC8128382","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}