{"doi":"10.1093/hmg/ddw319","title":"Genome-wide association study identifies<i>WNT7B</i>as a novel locus for central corneal thickness in Latinos","abstract":null,"journal":"Human Molecular Genetics","year":2016,"id":47550,"datarank":1.5604406649055687,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":1.0148027409466107,"self_endowment_contribution":0.5456379239589579,"citer_contribution":1.0148027409466107,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":32,"citers_with_citation_signal":26,"citers_with_endowment":26,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":130754,"name":"Drew R. Nannini","orcid":null,"position":1,"is_corresponding":false},{"id":219974,"name":"Kristen Corrao","orcid":null,"position":2,"is_corresponding":false},{"id":116282,"name":"Mina Torres","orcid":null,"position":3,"is_corresponding":false},{"id":130755,"name":"Yii-Der I. Chen","orcid":null,"position":4,"is_corresponding":false},{"id":6858,"name":"Bao J. Fan","orcid":null,"position":5,"is_corresponding":false},{"id":6851,"name":"Janey L. Wiggs","orcid":"0000-0003-1890-3278","position":6,"is_corresponding":false},{"id":116259,"name":"Kent D. Taylor","orcid":null,"position":8,"is_corresponding":false},{"id":219975,"name":"W. James Gauderman","orcid":null,"position":9,"is_corresponding":false},{"id":11276,"name":"Jerome I. Rotter","orcid":"0000-0001-7191-1723","position":10,"is_corresponding":false},{"id":116284,"name":"Rohit Varma","orcid":null,"position":11,"is_corresponding":false},{"id":112595,"name":"Xiaoyi Gao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genome-wide association study identifies<i>WNT7B</i>as a novel locus for central corneal thickness in Latinos","abstract":"The cornea is the outermost layer of the eye and is a vital component of focusing incoming light on the retina. Central corneal thickness (CCT) is now recognized to have a significant role in ocular health and is a risk factor for various ocular diseases, such as keratoconus and primary open angle glaucoma. Most previous genetic studies utilized European and Asian subjects to identify genetic loci associated with CCT. Minority populations, such as Latinos, may aid in identifying additional loci and improve our understanding of the genetic architecture of CCT. In this study, we conducted a genome-wide association study (GWAS) in Latinos, a traditionally understudied population in genetic research, to further identify loci contributing to CCT. Study participants were genotyped using either the Illumina OmniExpress BeadChip (∼730K markers) or the Illumina Hispanic/SOL BeadChip (∼2.5 million markers). All study participants were 40 years of age and older. We assessed the association between individual single nucleotide polymorphisms (SNPs) and CCT using linear regression, adjusting for age, gender and principal components of genetic ancestry. To expand genomic coverage and to interrogate additional SNPs, we imputed SNPs from the 1000 Genomes Project reference panels. We identified a novel SNP, rs10453441 (P = 6.01E-09), in an intron of WNT7B that is associated with CCT. Furthermore, WNT7B is expressed in the human cornea. We also replicated 11 previously reported loci, including IBTK, RXRA-COL5A1, COL5A1, FOXO1, LRRK1 and ZNF469 (P < 1.25E-3). These findings provide further insight into the genetic architecture of CCT and illustrate that the use of minority groups in GWAS will help identify additional loci.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28171582","pmcid":"PMC6078592","openalex_id":"https://openalex.org/W2523336485","authors":[],"funders":[{"funder_name":"NEI NIH HHS","grant_id":"P30 EY001792","title":null},{"funder_name":"NEI NIH HHS","grant_id":"P30 EY014104","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001881","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY022305","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK063491","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY022651","title":null},{"funder_name":"NEI NIH HHS","grant_id":"U10 EY011753","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000124","title":null},{"funder_name":"National Institutes of Health","grant_id":"3P30DK063491-04S1","title":"Diabetes Endocrinology Research Center"},{"funder_name":"National Institutes of Health","grant_id":"2P30EY001792-36A1","title":"Instrument Shop Core"},{"funder_name":"National Institutes of Health","grant_id":"3U10EY011753-03S4","title":"LOS ANGELES LATINO EYE STUDY"},{"funder_name":"National Institutes of Health","grant_id":"5UL1TR000124-04","title":"UCLA Clinical and Translational Science Institute"},{"funder_name":"National Institutes of Health","grant_id":"5R01EY022651-05","title":"Mexican American Glaucoma Genetic Study (MAGGS)"}],"total_grants":13,"fwci":5.4228,"citation_percentile":0.95722075,"influential_citations":4,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":6},{"year":2019,"count":9},{"year":2020,"count":6},{"year":2021,"count":6},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":"other-oa","oa_locations":[{"url":"https://academic.oup.com/hmg/article-pdf/25/22/5035/25419804/ddw319.pdf","host_type":"journal"},{"url":"https://academic.oup.com/hmg/article-pdf/25/22/5035/25419804/ddw319.pdf","host_type":"BRONZE"},{"url":"https://academic.oup.com/hmg/article-pdf/25/22/5035/25419804/ddw319.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/hmg/article/2525922/GenomeWide-Association-Study-Identifies-WNT7B-as-a","host_type":"publisher"},{"url":"https://doi.org/10.1093/hmg/ddw319","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28171582","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/d63616d6-9b23-4eb9-87a5-8b0681f3945e","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/7b5dae11-59c9-4322-9a08-7ebd0f69df2f","host_type":"repository"},{"url":"https://escholarship.org/uc/item/3nh9f21j","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6078592","host_type":"repository"},{"url":"https://dx.doi.org/10.1093/hmg/ddw319","host_type":""},{"url":"https://discovery-pp.ucl.ac.uk/id/eprint/10024533/","host_type":""},{"url":"https://escholarship.org/content/qt3nh9f21j/qt3nh9f21j.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1093/hmg/ddw319","host_type":""}],"fields_of_study":["Glaucoma and retinal disorders","Corneal surgery and disorders","Corneal Surgery and Treatments","Biology","Medicine","0302 clinical medicine","03 medical and health sciences","Adult","Aged","Cornea","Corneal Pachymetry","Female","Genetic Loci","Genome-Wide Association Study","Genotype","Glaucoma","Glaucoma, Open-Angle","Hispanic or Latino","Humans","Keratoconus","Los Angeles","Male","Middle Aged","Polymorphism, Single Nucleotide","Wnt Proteins"],"mesh_terms":["Adult","Aged","Cornea","Female","Genotype","Glaucoma","Glaucoma, Open-Angle","Hispanic or Latino","Humans","Keratoconus","Male","Middle Aged","Los Angeles","Polymorphism, Single Nucleotide","Wnt Proteins","Genome-Wide Association Study","Genetic Loci","Corneal Pachymetry"],"keywords":["Genome-wide association study","Single-nucleotide polymorphism","Genetic genealogy","Biology","Genetic architecture","1000 Genomes Project","Genetics","SNP","Population","Genetic association","Keratoconus","Locus (genetics)","Genotype","Quantitative trait locus","Cornea","Gene","Medicine","Male","Aging","retina","Corneal Pachymetry","introns","minority groups","imputation","Eye","Medical and Health Sciences","cornea eye genetics","forkhead box protein o1","single nucleotide polymorphism","2.1 Biological and endogenous factors","Genetics & Heredity","Single Nucleotide","Hispanic or Latino","Biological Sciences","Middle Aged","Los Angeles","Open-Angle","linear regression","Female","hispanics or latinos","Glaucoma, Open-Angle","Adult","570","asian","610","International Glaucoma Genetics Consortium","Polymorphism, Single Nucleotide","SDG 3 - Good Health and Well-being","Clinical Research","genome open-angle glaucoma","gender genetic research","Humans","Polymorphism","Eye Disease and Disorders of Vision","Eye diseases","Aged","Human Genome","Glaucoma","Wnt Proteins","Genetic Loci"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":10,"sdg_label":"10. No inequality"},{"sdg_number":16,"sdg_label":"16. Peace & justice"},{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T19:46:11.143340Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}