{"doi":"10.1093/hmg/ddr308","title":"Altered palmitoylation and neuropathological deficits in mice lacking HIP14","abstract":null,"journal":"Human Molecular Genetics","year":2011,"id":648597,"datarank":3.401910688238756,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":2.6901708689842687,"self_endowment_contribution":0.7117398192544876,"citer_contribution":2.6901708689842687,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":90,"citers_with_citation_signal":79,"citers_with_endowment":79,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1107876,"name":"K. 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In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice displayed behavioral, biochemical and neuropathological defects that are reminiscent of Huntington disease (HD). Palmitoylation of other HIP14 substrates, but not Htt, was reduced in the Hip14-/- mice. Hip14 is dysfunctional in the presence of mutant htt in the YAC128 mouse model of HD, suggesting that altered palmitoylation mediated by HIP14 may contribute to HD.","is_dataset_classified":null,"base_score":4.74493212836325,"endowment":4.74493212836325,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21775500","pmcid":"PMC3177655","openalex_id":"https://openalex.org/W2129096803","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS043782","title":null},{"funder_name":"CIHR","grant_id":"MOP-84438","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM65525","title":null},{"funder_name":"CIHR","grant_id":"GPG-102165","title":null},{"funder_name":"CIHR","grant_id":"MOP-12699","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"P01 DA019695","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM065525","title":null}],"total_grants":7,"fwci":3.4882,"citation_percentile":0.93868945,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":9},{"year":2014,"count":12},{"year":2015,"count":19},{"year":2016,"count":8},{"year":2017,"count":8},{"year":2018,"count":3},{"year":2019,"count":8},{"year":2020,"count":8},{"year":2021,"count":7},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":6},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/hmg/article-pdf/20/20/3899/17252686/ddr308.pdf","host_type":"journal"},{"url":"https://academic.oup.com/hmg/article-pdf/20/20/3899/17252686/ddr308.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/hmg/article-pdf/20/20/3899/17252686/ddr308.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/hmg/ddr308","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21775500","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3177655","host_type":"repository"}],"fields_of_study":["Genetic Neurodegenerative Diseases","Mitochondrial Function and Pathology","Muscle Physiology and Disorders"],"mesh_terms":["Acyltransferases","Animals","Corpus Striatum","Disease Models, Animal","Enkephalins","Huntington Disease","Motor Activity","Nerve Tissue Proteins","Neurons","Synapses","Cell Death","Mice, Knockout","Serotonin Plasma Membrane Transport Proteins","Mutant Proteins","Mice","Dopamine and cAMP-Regulated Phosphoprotein 32","Lipoylation"],"keywords":["Huntingtin","Palmitoylation","Biology","Mutant","Huntingtin Protein","Huntington's disease","Cell biology","Neuroscience","Gene","Genetics","Internal medicine","Biochemistry","Disease","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:46:49.585285Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}