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Six genomic regions on chromosomes 2p23, 3p12, 3q26, 12p13-q21, 18q21-q23 and Xq27 showed heterogeneity LOD (HLOD) scores of greater than 1, with a maximum HLOD of 1.94 at 3q26. Genome-wide simulation studies indicate that the observed number of HLOD peaks greater than one does not differ significantly from that expected by chance. A TGCT locus at Xq27 has been previously reported. Of the 237 pedigrees examined in this study, 66 were previously unstudied at Xq27, no evidence for linkage to this region was observed in this new pedigree set. Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16407372","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"1R01 CA102042-01A1","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01CA102042-05","title":"A Genetic Linkage Study of Testicular Cancer"},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/hmg/article-pdf/15/3/443/1756891/ddi459.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/hmg/article-pdf/15/3/443/1756891/ddi459.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/hmg/ddi459","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/16407372","host_type":""},{"url":"https://dx.doi.org/10.1093/hmg/ddi459","host_type":""},{"url":"https://inserm.hal.science/inserm-00127763v1/document","host_type":""},{"url":"https://inserm.hal.science/inserm-00127763v1","host_type":""},{"url":"https://doi.org/https://doi.org/10.1093/hmg/ddi459","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Chromosomes, Human, X","Humans","Neoplasms, Germ Cell and Embryonal","Testicular Neoplasms","Genetic Predisposition to Disease","Chromosome Mapping","Pedigree","Lod Score","Genetic Heterogeneity","Genome, Human","Female","Male","Genetic Linkage"],"keywords":["Male","MESH: Pedigree","Genetic Linkage","610","576","Genetic Heterogeneity","Testicular Neoplasms","Humans","MESH: Neoplasms","MESH: Genome","Genetic Predisposition to Disease","MESH: Testicular Neoplasms","X","Chromosomes, Human, X","MESH: Humans","Genome, Human","MESH: Genetic Heterogeneity","MESH: Genetic Predisposition to Disease","Chromosome Mapping","Neoplasms, Germ Cell and Embryonal","MESH: Male","Pedigree","MESH: Lod Score","[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie","Germ Cell and Embryonal","MESH: Chromosomes","[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie","Female","Lod Score","MESH: Chromosome Mapping","MESH: Female","MESH: Linkage (Genetics)","Human"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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