{"doi":"10.1093/hmg/ddae130","title":"Schizophrenia risk-associated SNPs affect expression of microRNA 137 host gene: a postmortem study","abstract":"Common variants in the MicroRNA 137 host gene MIR137HG and its adjacent gene DPYD have been associated with schizophrenia risk and the latest Psychiatric Genomics Consortium (PGC). Genome-Wide Association Study on schizophrenia has confirmed and extended these findings. To elucidate the association of schizophrenia risk-associated SNPs in this genomic region, we examined the expression of both mature and immature transcripts of the miR-137 host gene (MIR137HG) in the dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex (sgACC) of postmortem brain samples of donors with schizophrenia and psychiatrically-unaffected controls using qPCR and RNA-Seq approaches. No differential expression of miR-137, MIR137HG, or its transcripts was observed. Two schizophrenia risk-associated SNPs identified in the PGC study, rs11165917 (DLPFC: P = 2.0e-16; sgACC: P = 6.4e-10) and rs4274102 (DLPFC: P = 0.036; sgACC: P = 0.002), were associated with expression of the MIR137HG long non-coding RNA transcript MIR137HG-203 (ENST00000602672.2) in individuals of European ancestry. Carriers of the minor (risk) allele of rs11165917 had significantly lower expression of MIR137HG-203 compared with those carrying the major allele. However, we were unable to validate this result by short-read sequencing of RNA extracted from DLPFC or sgACC tissue. This finding suggests that immature transcripts of MIR137HG may contribute to genetic risk for schizophrenia.","journal":"Human Molecular Genetics","year":2024,"id":477487,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9339,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":863910,"name":"Ajeet Mandal","orcid":null,"position":1,"is_corresponding":false},{"id":84474,"name":"Ananya Jambhale","orcid":null,"position":2,"is_corresponding":false},{"id":1316137,"name":"Pranav Narnur","orcid":null,"position":3,"is_corresponding":false},{"id":1315763,"name":"Gang Chen","orcid":"0000-0003-1502-0330","position":4,"is_corresponding":false},{"id":54799,"name":"Nirmala Akula","orcid":"0000-0002-6782-5694","position":5,"is_corresponding":false},{"id":348987,"name":"Robin S. S. Kramer","orcid":"0000-0001-8339-8832","position":6,"is_corresponding":false},{"id":507073,"name":"Bhaskar Kolachana","orcid":"0000-0001-9606-1497","position":7,"is_corresponding":false},{"id":355203,"name":"Qing Xu","orcid":"0000-0001-9479-470X","position":8,"is_corresponding":false},{"id":37374,"name":"Francis J. McMahon","orcid":"0000-0002-9469-305X","position":9,"is_corresponding":false},{"id":349773,"name":"Barbara K. Lipska","orcid":null,"position":10,"is_corresponding":false},{"id":462346,"name":"Pavan K. Auluck","orcid":null,"position":11,"is_corresponding":false},{"id":6267,"name":"Stefano Marenco","orcid":"0000-0002-2488-2365","position":12,"is_corresponding":false},{"id":1315762,"name":"Ningping Feng","orcid":"0009-0003-9830-3105","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:06:37.812633Z","pmid":"39239979","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}