{"doi":"10.1093/hmg/ddaa021","title":"Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1","abstract":"Individuals with pseudoexfoliation (PEX) syndrome exhibit various connective tissue pathologies associated with dysregulated extracellular matrix homeostasis. PEX glaucoma is a common, aggressive form of open-angle glaucoma resulting from the deposition of fibrillary material in the conventional outflow pathway. However, the molecular mechanisms that drive pathogenesis and genetic risk remain poorly understood. PEX glaucoma-associated single-nucleotide polymorphisms are located in and affect activity of the promoter of LOXL1-AS1, a long non-coding RNA (lncRNA). Nuclear and non-nuclear lncRNAs regulate a host of biological processes, and when dysregulated, contribute to disease. Here we report that LOXL1-AS1 localizes to the nucleus where it selectively binds to the mRNA processing protein, heterogeneous nuclear ribonucleoprotein-L (hnRNPL). Both components of this complex are critical for the regulation of global gene expression in ocular cells, making LOXL1-AS1 a prime target for investigation in PEX syndrome and glaucoma.","journal":"Human Molecular Genetics","year":2020,"id":76231,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398741,"name":"William M. Johnson","orcid":null,"position":1,"is_corresponding":false},{"id":397592,"name":"Inas F. Aboobakar","orcid":"0000-0002-4556-8818","position":2,"is_corresponding":false},{"id":398742,"name":"Shelby Strickland","orcid":null,"position":3,"is_corresponding":false},{"id":394142,"name":"María Gomez‐Caraballo","orcid":null,"position":4,"is_corresponding":false},{"id":398743,"name":"Megan Parker","orcid":null,"position":5,"is_corresponding":false},{"id":397593,"name":"Laura K. Finnegan","orcid":"0000-0002-3395-1211","position":6,"is_corresponding":false},{"id":65837,"name":"David L. Corcoran","orcid":"0000-0001-7460-9247","position":7,"is_corresponding":false},{"id":268118,"name":"Nikolai P. Skiba","orcid":"0000-0002-9572-1585","position":8,"is_corresponding":false},{"id":6855,"name":"R. Rand Allingham","orcid":null,"position":9,"is_corresponding":false},{"id":6853,"name":"Michael A. Hauser","orcid":"0000-0003-2667-5420","position":10,"is_corresponding":false},{"id":292183,"name":"W. Daniel Stamer","orcid":"0000-0002-2504-8997","position":11,"is_corresponding":false},{"id":335076,"name":"H Schmitt","orcid":"0000-0003-2007-7542","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T21:47:46.469293Z","pmid":"32037441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}