{"doi":"10.1093/geroni/igx004.2098","title":"HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVEL AND COGNITION IN OLD AGE: THE ROLE OF COGNITIVE RESERVE","abstract":null,"journal":"Innovation in Aging","year":2017,"id":639284,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1660816,"name":"E.R. Gouveia","orcid":null,"position":1,"is_corresponding":false},{"id":1660817,"name":"B.R. Gouveia","orcid":null,"position":2,"is_corresponding":false},{"id":1660818,"name":"D.L. Freitas","orcid":null,"position":3,"is_corresponding":false},{"id":1660819,"name":"J. Jurema","orcid":null,"position":4,"is_corresponding":false},{"id":1660820,"name":"M.A. Tinôco","orcid":null,"position":5,"is_corresponding":false},{"id":1660821,"name":"M. Kliegel","orcid":null,"position":6,"is_corresponding":false},{"id":1660815,"name":"A. Ihle","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVEL AND COGNITION IN OLD AGE: THE ROLE OF COGNITIVE RESERVE","abstract":"It remains unclear so far whether the negative relation of critically low high-density lipoprotein cholesterol (HDL-C) level to cognitive functioning in old age may be reduced in individuals with higher cognitive reserve accumulated during the life course. Therefore, the present study set out to investigate the relation of HDL-C level to cognitive performance and its interplay with key markers of cognitive reserve (education, cognitive level of job, and cognitive leisure activity) in a large sample of older adults. We assessed tests of working, short-term, and long-term memory in 701 older adults (mean age = 70.4 years) from Fonte Boa, Apuí, and Manaus, Brazil. HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity. Results showed that critically low HDL-C level (< 40 mg/dl) was significantly related to lower performance in working memory (r = -.28, p < .001), short-term memory (r = -.24, p < .001), and long-term memory (r = -.24, p < .001). These relations were significantly moderated by education, cognitive level of job, and cognitive leisure activity (βs >= .08, ps < .05). Subsequent analyses revealed that the relation of HDL-C level to cognitive performance was negligible in individuals with longer education, higher cognitive level of job, and greater engaging in cognitive leisure activity (βs < .07, ps > .05). In conclusion, cognitive reserve accumulated during the life course may reduce the detrimental influences of a low HDL-C level on cognitive functioning in old age.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":"PMC6246582","openalex_id":"https://openalex.org/W2725587666","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://academic.oup.com/innovateage/article-pdf/1/suppl_1/599/26098200/igx004.2098.pdf","host_type":"journal"},{"url":"https://academic.oup.com/innovateage/article-pdf/1/suppl_1/599/26098200/igx004.2098.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/innovateage/article-pdf/1/suppl_1/599/26098200/igx004.2098.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/geroni/igx004.2098","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6246582","host_type":"repository"}],"fields_of_study":["Cardiovascular Health and Disease Prevention","Blood Pressure and Hypertension Studies","Cerebrovascular and Carotid Artery Diseases"],"mesh_terms":[],"keywords":["Cognitive reserve","Cognition","Effects of sleep deprivation on cognitive performance","Cognitive decline","Psychology","Cognitive skill","Gerontology","Working memory","Medicine","Cognitive impairment","Internal medicine","Dementia","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T23:44:24.815415Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}