{"doi":"10.1093/geroni/igad132","title":"Timed Activity to Minimize Sleep Disturbance in People With Cognitive Impairment","abstract":"Abstract Background and Objectives Sleep disturbances occur in >60% of persons living with cognitive impairment, affecting their quality of life (QOL). Regulating the sleep–wake cycle through engaging cognitive, physical, and sensory-based activities delivered at strategic times may reduce sleep disturbances and be a feasible nonpharmacological treatment for sleep problems. The objective of this trial was to test the efficacy of a timed-activity intervention in improving QOL and sleep disturbances in persons living with cognitive impairment. Research Design and Method Randomized 2-group parallel design involving 209 dyads of community-residing persons living with cognitive impairment and care partners. Dyads were randomly assigned (1:1) to 1-hr home activity sessions administered weekly in the morning, afternoon, or evening over 4 weeks (the Healthy Patterns Sleep Program), or to an attention-control condition consisting of sleep hygiene training plus education on home safety and health promotion. QOL, objective and subjective sleep quality, and neuropsychiatric symptoms were assessed at baseline and 4 weeks later. Results QOL was significantly improved in the intervention group compared to control (p = .0491). There were no significant effects on objective or subjective sleep or neuropsychiatric symptoms. In a subgroup analysis, subjective sleep as measured by the PROMIS (Patient Reported Outcomes Measurement Information System) Sleep-Related Impairment survey was significantly improved in the intervention group compared to the control group for individuals with symptoms of depression (p = .015) or poor observed sleep at baseline (p = .005). Discussion and Implications The Healthy Patterns Intervention may benefit QOL for persons living with cognitive impairment and those with poor subjective sleep. A longer dose may be necessary to elicit improvement in actigraphically measured sleep–wake activity. Clinical Trial Registration Number NCT0368218 5","journal":"Innovation in Aging","year":2023,"id":350560,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":468957,"name":"Miranda McPhillips","orcid":"0000-0002-0741-1545","position":1,"is_corresponding":false},{"id":378805,"name":"Darina Petrovsky","orcid":"0000-0002-3109-1633","position":2,"is_corresponding":false},{"id":429957,"name":"Adriana Pérez","orcid":"0000-0003-1143-2629","position":3,"is_corresponding":false},{"id":737191,"name":"Sonia Talwar","orcid":"0000-0001-7546-5281","position":4,"is_corresponding":false},{"id":737899,"name":"Nalaka S. Gooneratne","orcid":null,"position":5,"is_corresponding":false},{"id":97074,"name":"Bárbara Riegel","orcid":"0000-0002-0970-136X","position":6,"is_corresponding":false},{"id":772645,"name":"Subhash Aryal","orcid":"0000-0002-8300-1484","position":7,"is_corresponding":false},{"id":361969,"name":"Laura N. Gitlin","orcid":"0000-0003-2869-473X","position":8,"is_corresponding":false},{"id":378804,"name":"Nancy Hodgson","orcid":"0000-0001-8862-9986","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:12:37.409066Z","pmid":"38235487","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}