{"doi":"10.1093/gerona/gly071","title":"Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele","abstract":null,"journal":"The Journals of Gerontology: Series A","year":2018,"id":619932,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1600049,"name":"D Craig Willcox","orcid":null,"position":1,"is_corresponding":false},{"id":1312719,"name":"Michio Shimabukuro","orcid":"0000-0001-7835-7665","position":2,"is_corresponding":false},{"id":1600050,"name":"Timothy A Donlon","orcid":null,"position":3,"is_corresponding":false},{"id":767122,"name":"Trevor Torigoe","orcid":"0000-0003-2158-9005","position":4,"is_corresponding":false},{"id":1326947,"name":"Makoto Suzuki","orcid":"0000-0002-5494-6593","position":5,"is_corresponding":false},{"id":1313087,"name":"Moritake Higa","orcid":null,"position":6,"is_corresponding":false},{"id":1600051,"name":"Hiroaki Masuzaki","orcid":null,"position":7,"is_corresponding":false},{"id":704956,"name":"Masataka Sata","orcid":"0000-0002-8036-7501","position":8,"is_corresponding":false},{"id":372084,"name":"Randi Chen","orcid":"0000-0003-3747-7964","position":9,"is_corresponding":false},{"id":1600052,"name":"Rachel L Murkofsky","orcid":null,"position":10,"is_corresponding":false},{"id":1600053,"name":"Brian J Morris","orcid":null,"position":11,"is_corresponding":false},{"id":520709,"name":"Eunjung Lim","orcid":"0000-0002-3056-1269","position":12,"is_corresponding":false},{"id":1600056,"name":"Richard C Allsopp","orcid":null,"position":13,"is_corresponding":false},{"id":1600058,"name":"Bradley J Willcox","orcid":null,"position":14,"is_corresponding":false},{"id":1600048,"name":"Philip M C Davy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele","abstract":"FOXO3 is one of the most prominent genes demonstrating a consistently reproducible genetic association with human longevity. The mechanisms by which these individual gene variants confer greater organismal lifespan are not well understood. We assessed the effect of longevity-associated FOXO3 alleles on age-related leukocyte telomere dynamics in a cross-sectional study comprised of samples from 121 healthy Okinawan-Japanese donors aged 21-95 years. We found that telomere length for carriers of the longevity associated allele of FOXO3 single nucleotide polymorphism rs2802292 displayed no significant correlation with age, an effect that was most pronounced in older (>50 years of age) participants. This is the first validated longevity gene variant identified to date showing an association with negligible loss of telomere length with age in humans in a cross-sectional study. Reduced telomere attrition may be a key mechanism for the longevity-promoting effect of the FOXO3 genotype studied.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29688278","pmcid":"PMC6175018","openalex_id":"https://openalex.org/W2801353961","authors":[],"funders":[{"funder_name":"National Institute on Aging","grant_id":"R21OAG04298","title":null},{"funder_name":"Ministry of Education, Culture, Sports, Science and Technology","grant_id":"16K01823","title":null},{"funder_name":"National Institutes of Health","grant_id":"U54MD007584","title":null},{"funder_name":"National Institutes of Health","grant_id":"G12MD007601","title":null},{"funder_name":"NIMHD NIH HHS","grant_id":"U54 MD007601","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U54MD007584-07","title":"RCMI Multidisciplinary And Translational Research Infrastructure EXpansion (RAMAT"},{"funder_name":"National Institutes of Health","grant_id":"2U54MD007601-31","title":"Ola HAWAII"}],"total_grants":7,"fwci":1.2589,"citation_percentile":0.78681539,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2026,"count":1}],"oa_status":"bronze","license":"OUP Standard Publication Reuse","oa_locations":[{"url":"https://academic.oup.com/biomedgerontology/article-pdf/73/11/1448/25960978/gly071.pdf","host_type":"journal"},{"url":"https://academic.oup.com/biomedgerontology/article-pdf/73/11/1448/25960978/gly071.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/biomedgerontology/article-pdf/73/11/1448/25960978/gly071.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/gerona/gly071","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29688278","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6175018","host_type":"repository"},{"url":"https://dx.doi.org/10.1093/gerona/gly071","host_type":""}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Genetics, Aging, and Longevity in Model Organisms","FOXO transcription factor regulation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adult","Aged","Aged, 80 and over","Alleles","Asian People","Cross-Sectional Studies","Female","Forkhead Box Protein O3","Genotype","Heterozygote","Humans","Japan","Leukocytes","Longevity","Male","Middle Aged","Polymorphism, Single Nucleotide","Telomere Shortening","Young Adult"],"mesh_terms":["Forkhead Box Protein O3","Adult","Aged","Aged, 80 and over","Alleles","Cross-Sectional Studies","Female","Genotype","Heterozygote","Humans","Japan","Leukocytes","Longevity","Male","Middle Aged","Polymorphism, Single Nucleotide","Asian People","Young Adult","Telomere Shortening"],"keywords":["Longevity","FOXO3","Telomere","Allele","Biology","Single-nucleotide polymorphism","Genetics","Genotype","Gene","Transcription factor","Adult","Aged, 80 and over","Male","Heterozygote","Forkhead Box Protein O3","Middle Aged","Polymorphism, Single Nucleotide","Young Adult","Cross-Sectional Studies","Asian People","Japan","Leukocytes","Humans","Female","Alleles","Telomere Shortening","Aged"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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