{"doi":"10.1093/gerona/glae170","title":"Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults","abstract":"BACKGROUND: Mitochondrial dysfunction manifests in neurodegenerative diseases and other age-associated disorders. In this study, we examined variation in inherited mitochondrial DNA (mtDNA) sequences in Black and White participants from 2 large aging studies to identify variants related to cognitive function. METHODS: Participants included self-reported Black and White adults aged ≥70 years in the Lifestyle Interventions and Independence for Elders (LIFE; N = 1 319) and Health Aging and Body Composition (Health ABC; N = 788) studies. Cognitive function was measured by the Digit-Symbol Substitution Test (DSST), and the Modified Mini-Mental State Examination (3MSE) at baseline and over follow-up in LIFE (3.6 years) and Health ABC (10 years). We examined the joint effects of multiple variants across 16 functional mitochondrial regions with cognitive function using a sequence kernel association test. Based on these results, we prioritized meta-analysis of common variants in Black and White participants using mixed effects models. A Bonferroni-adjusted p value of <.05 was considered statistically significant. RESULTS: Joint variation in subunits ND1, ND2, and ND5 of Complex I, 12S RNA, and hypervariable region (HVR) were significantly associated with DSST and 3MSE at baseline. In meta-analyses among Black participants, variant m.4216T>C, ND1 was associated with a faster decline in 3MSE, and variant m.462C>T in the HVR was associated with a slower decline in DSST. Variant m.5460G>C, ND2 was associated with slower and m.182C>T in the HVR was associated with faster decline in 3MSE in White participants. CONCLUSIONS: Among Black and White adults, oxidative phosphorylation Complex I variants were associated with cognitive function.","journal":"The Journals of Gerontology Series A","year":2024,"id":471419,"datarank":0.20325750903735637,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.038465665737139915,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.038465665737139915,"corpus_percentile":34.96557592635569,"corpus_rank":8408,"citation_count":2,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6107,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1305917,"name":"Yongmei Li","orcid":"0000-0003-1808-6060","position":1,"is_corresponding":false},{"id":290909,"name":"Vasantha Jotwani","orcid":"0000-0003-1913-3957","position":2,"is_corresponding":false},{"id":1305918,"name":"Sylvie Dobrota","orcid":"0000-0001-5134-2105","position":3,"is_corresponding":false},{"id":1146602,"name":"Annabel X. Tan","orcid":"0000-0001-8368-0301","position":4,"is_corresponding":false},{"id":74871,"name":"Steven R. Cummings","orcid":"0000-0001-8808-260X","position":5,"is_corresponding":false},{"id":19396,"name":"Michael G. Shlipak","orcid":"0000-0002-9559-204X","position":6,"is_corresponding":false},{"id":338912,"name":"Rebecca Scherzer","orcid":"0000-0002-1579-5390","position":7,"is_corresponding":false},{"id":261907,"name":"Joachim H. Ix","orcid":"0000-0002-8084-9869","position":8,"is_corresponding":false},{"id":68265,"name":"Marion S. Buckwalter","orcid":"0000-0003-2807-2447","position":9,"is_corresponding":false},{"id":689310,"name":"Gregory J. Tranah","orcid":"0000-0002-5520-812X","position":10,"is_corresponding":false},{"id":305264,"name":"Michelle C. Odden","orcid":"0000-0002-5974-3648","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:05:44.736405Z","pmid":"39007867","pmcid":"PMC11345514","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}