{"doi":"10.1093/gerona/glae078","title":"Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness, and Bone Density After Hip Fracture","abstract":"BACKGROUND: Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of 2 different home-based physical therapy programs on muscle area and attenuation (reflects muscle density) of the lower extremities, bone mineral density (BMD), and aerobic capacity. METHODS: Randomized controlled trial of home-based 16 weeks of strength, endurance, balance, and function exercises (PUSH, n = 19) compared to seated active range-of-motion exercises and transcutaneous electrical neurostimulation (PULSE, n = 18) in community-dwelling adults >60 years of age within 26 weeks of hip fracture. RESULTS: In PUSH and PULSE groups combined, the fractured leg had lower muscle area and muscle attenuation and higher subcutaneous fat than the nonfractured leg (p < .001) at baseline. At 16 weeks, mean muscle area of the fractured leg was higher in the PUSH than PULSE group (p = .04). Changes in muscle area were not significantly different when compared to the comparative PULSE group. There was a clinically relevant difference in change in femoral neck BMD between groups (p = .05) that showed an increase after PULSE and decrease after PUSH. There were generally no between-group differences in mean VO2peak tests at 16-week follow-up, except the PUSH group reached a higher max incline (p = .04). CONCLUSIONS: The treatment effects of a multicomponent home-based physical therapy intervention on muscle composition, BMD, and aerobic capacity were not significantly different than an active control intervention in older adults recovering from hip fracture. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01783704.","journal":"The Journals of Gerontology Series A","year":2024,"id":479614,"datarank":0.1162465584064075,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.012274481322415697,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.012274481322415697,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01783704"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409771,"name":"Brock A. Beamer","orcid":"0000-0002-6941-0898","position":1,"is_corresponding":false},{"id":539245,"name":"Ann L. Gruber‐Baldini","orcid":"0000-0002-0190-1973","position":2,"is_corresponding":false},{"id":754861,"name":"Rebecca L. Craik","orcid":"0000-0003-4816-1439","position":3,"is_corresponding":false},{"id":1151730,"name":"Justine Golden","orcid":null,"position":4,"is_corresponding":false},{"id":45775,"name":"Jack M. Guralnik","orcid":"0000-0001-5108-7263","position":5,"is_corresponding":false},{"id":31642,"name":"Marc C. Hochberg","orcid":"0000-0001-7705-5593","position":6,"is_corresponding":false},{"id":754860,"name":"Kathleen K Mangione","orcid":"0000-0003-1214-4426","position":7,"is_corresponding":false},{"id":109432,"name":"Denise Orwig","orcid":"0000-0003-4095-5795","position":8,"is_corresponding":false},{"id":478450,"name":"Alan M. Rathbun","orcid":"0000-0003-3611-5494","position":9,"is_corresponding":false},{"id":109420,"name":"Jay Magaziner","orcid":null,"position":10,"is_corresponding":false},{"id":389916,"name":"Alice S. Ryan","orcid":"0000-0003-3708-110X","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:06:54.284166Z","pmid":"38452133","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}