{"doi":"10.1093/gerona/glad268","title":"Low-Density-Lipoprotein Cholesterol and Mortality Outcomes Among Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial","abstract":"BACKGROUND: The prognostic implication of cholesterol levels in older adults remains uncertain. This study aimed to examine the relationship between low-density-lipoprotein cholesterol (LDL-c) and mortality outcomes in older individuals. METHODS: This post hoc analysis examined the associations of LDL-c levels with mortality risks from all-cause, cardiovascular disease (CVD), cancer, and combined non-CVD/noncancer conditions in a cohort of individuals aged ≥65 years from the ASPirin in Reducing Events in the Elderly trial (NCT01038583). At baseline, participants had no diagnosed dementia, physical disability, or CVD, and were not taking lipid-lowering agents. Outcome analyses were performed using multivariable Cox models. RESULTS: We analyzed 12 334 participants (mean age: 75.2 years). Over a median 7-year follow-up, 1 250 died. Restricted cubic splines found a U-shaped relation for LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVE mortality (nadir: 3.3-3.4 mmol/L); the risk of CVD mortality was similar at LDL-c below 3.3 mmol/L and increased above 3.3 mmol/L. Similar trends were observed in analyses modeling LDL-c by quartiles. When modeling LDL-c as a continuous variable, the risk of all-cause mortality, cancer mortality, and noncancer/non-CVD mortality was decreased by 9%, 16%, and 18%, respectively, per 1-mmol/L higher LDL-c, and the risk of CVD mortality was increased by 19% per 1-mmol/L higher LDL-c. Reduced all-cause and non-CVD/noncancer mortality risks were only significant in males but not females (pinteraction < .05). CONCLUSIONS: There were U-shaped relationships between LDL-c and all-cause mortality, cancer mortality, and noncancer/non-CVD mortality in healthy older adults. Higher LDL-c levels were associated with an increased risk of CVD mortality. Future studies are warranted to confirm our results.","journal":"The Journals of Gerontology Series A","year":2023,"id":345377,"datarank":0.5126934601445002,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.11683486070221134,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.11683486070221134,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":12,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01038583"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":284811,"name":"Andrew Tonkin","orcid":"0000-0001-5291-0610","position":1,"is_corresponding":false},{"id":636787,"name":"Andrea J. Curtis","orcid":"0000-0003-2407-770X","position":2,"is_corresponding":false},{"id":104607,"name":"Anne M. Murray","orcid":"0000-0002-2787-8433","position":3,"is_corresponding":false},{"id":1084858,"name":"Chao Zhu","orcid":"0000-0003-3951-7501","position":4,"is_corresponding":false},{"id":264296,"name":"Christopher M. Reid","orcid":"0000-0001-9173-3944","position":5,"is_corresponding":false},{"id":295973,"name":"Jeff D. Williamson","orcid":"0000-0002-0185-5823","position":6,"is_corresponding":false},{"id":332013,"name":"Joanne Ryan","orcid":"0000-0002-7039-6325","position":7,"is_corresponding":false},{"id":264297,"name":"John J. McNeil","orcid":"0000-0002-1049-5129","position":8,"is_corresponding":false},{"id":241477,"name":"Lawrence J. Beilin","orcid":"0000-0003-4853-7360","position":9,"is_corresponding":false},{"id":104597,"name":"Michael E. Ernst","orcid":"0000-0003-0267-4888","position":10,"is_corresponding":false},{"id":404574,"name":"Nigel Stocks","orcid":"0000-0002-9018-0361","position":11,"is_corresponding":false},{"id":301792,"name":"Paul Lacaze","orcid":"0000-0002-0902-6798","position":12,"is_corresponding":false},{"id":284810,"name":"Raj C. Shah","orcid":"0000-0001-9706-9730","position":13,"is_corresponding":false},{"id":264292,"name":"Robyn L. Woods","orcid":"0000-0003-1249-6149","position":14,"is_corresponding":false},{"id":264293,"name":"Rory Wolfe","orcid":"0000-0002-2126-1045","position":15,"is_corresponding":false},{"id":73164,"name":"Seana Gall","orcid":"0000-0002-5138-2526","position":16,"is_corresponding":false},{"id":236352,"name":"Sophia Zoungas","orcid":"0000-0003-2672-0949","position":17,"is_corresponding":false},{"id":351162,"name":"Suzanne G. Orchard","orcid":"0000-0003-0211-3183","position":18,"is_corresponding":false},{"id":264294,"name":"Mark Nelson","orcid":"0000-0001-9941-7161","position":19,"is_corresponding":false},{"id":636786,"name":"Zhen Zhou","orcid":"0000-0002-0835-8686","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:11:39.484741Z","pmid":"38038339","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}