{"doi":"10.1093/gerona/glad164","title":"The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers","abstract":"BACKGROUND: A recent study suggested that the protective effect of familial longevity becomes negligible for centenarians. However, the authors assessed the dependence on familial longevity in centenarians by comparing centenarians with 1 parent surviving to age 80+ to centenarians whose same-sexed parent did not survive to age 80. Here we test whether the protective effect of familial longevity persists after age 100 using more restrictive definitions of long-lived families. METHODS: Long-lived sibships were identified through 3 nationwide, consecutive studies in Denmark, including families with either at least 2 siblings aged 90+ or a Family Longevity Selection Score (FLoSS) above 7. Long-lived siblings enrolled in these studies and who reached age 100 were included. For each sibling, 5 controls matched on sex and year of birth were randomly selected among centenarians in the Danish population. Survival time from age 100 was described with Kaplan-Meier curves for siblings and controls separately. Survival analyses were performed using stratified Cox proportional hazards models. RESULTS: A total of 340 individuals from long-lived sibships who survived to age 100 and 1 700 controls were included. Among the long-lived siblings and controls, 1 650 (81%) were women. The results showed that long-lived siblings presented better overall survival after age 100 than sporadic long-livers (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.71-0.91), with even lower estimate (HR = 0.65, 95% CI = 0.50-0.85) if familial longevity was defined by FLoSS. CONCLUSIONS: The present study, with virtually no loss to follow-up, demonstrated a persistence of protective effect of familial longevity after age 100.","journal":"The Journals of Gerontology Series A","year":2023,"id":378796,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9589,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":363524,"name":"Jacob Krabbe Pedersen","orcid":"0000-0002-9042-0492","position":1,"is_corresponding":false},{"id":21849,"name":"Mary K. Wojczynski","orcid":null,"position":2,"is_corresponding":false},{"id":264268,"name":"Svetlana Ukraintseva","orcid":"0000-0002-0079-5494","position":3,"is_corresponding":false},{"id":280707,"name":"Konstantin G. Arbeev","orcid":"0000-0002-4195-7832","position":4,"is_corresponding":false},{"id":21696,"name":"Mary F. Feitosa","orcid":"0000-0002-0933-2410","position":5,"is_corresponding":false},{"id":324210,"name":"Michael A. Province","orcid":"0000-0001-6102-774X","position":6,"is_corresponding":false},{"id":38571,"name":"Kaare Christensen","orcid":"0000-0002-5429-5292","position":7,"is_corresponding":false},{"id":432025,"name":"Angéline Galvin","orcid":"0000-0001-9957-5418","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-19T01:16:48.594070Z","pmid":"37449765","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}