{"doi":"10.1093/gerona/glac190","title":"The Association of Epigenetic Age Acceleration and Multimorbidity at Age 90 in the Women’s Health Initiative","abstract":"BACKGROUND: Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk of several age-related chronic conditions. This is the first study to prospectively examine the relationship between EAA and both multimorbidity count and a weighted multimorbidity score among long-lived postmenopausal women. METHODS: We included 1 951 women from the Women's Health Initiative who could have survived to age 90. EAA was estimated using the Horvath pan-tissue, Hannum, PhenoAge, and GrimAge \"clocks.\" Twelve chronic conditions were included in the multimorbidity count. The multimorbidity score was weighted for each morbidity's relationship with mortality in the study population. Using mixed-effects Poisson and linear regression models that included baseline covariates associated with both EAA and multimorbidity, we estimated relative risks (RRs) and 95% confidence intervals (CIs) for the relationships between each EAA measure at the study baseline with both multimorbidity count and weighted multimorbidity score at age 90, respectively. RESULTS: For every one standard deviation increase in AgeAccelPheno, the rate of multimorbidity accumulation increased 6% (RR = 1.06; 95% CI = 1.01-1.12; p = .025) and the multimorbidity score by 7% (RR = 1.07; 95% CI = 1.01-1.13; p = .014) for women who survived to age 90. The results for a one standard deviation increase in AgeAccelHorvath, AgeAccelHannum, and AgeAccelGrim with multimorbidity accumulation and score were weaker compared to AgeAccelPheno, and the latter 2 did not reach statistical significance. CONCLUSION: AgeAccelPheno and AgeAccelHannum may predict multimorbidity count and score at age 90 in older women and, thus, may be useful as a biomarker predictor of multimorbidity burden in the last decades of life.","journal":"The Journals of Gerontology Series A","year":2022,"id":255716,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":424502,"name":"Alexandra M. Binder","orcid":"0000-0003-2949-4684","position":1,"is_corresponding":false},{"id":334854,"name":"Brian Chen","orcid":"0000-0001-6384-1673","position":2,"is_corresponding":false},{"id":493872,"name":"Humberto Parada","orcid":"0000-0001-6562-8577","position":3,"is_corresponding":false},{"id":421766,"name":"Linda C. Gallo","orcid":"0000-0002-3678-5888","position":4,"is_corresponding":false},{"id":462762,"name":"John E. Alcaraz","orcid":null,"position":5,"is_corresponding":false},{"id":38267,"name":"Steve Horvath","orcid":"0000-0002-4110-3589","position":6,"is_corresponding":false},{"id":393077,"name":"Parveen Bhatti","orcid":"0000-0003-1709-1781","position":7,"is_corresponding":false},{"id":218550,"name":"Eric A. Whitsel","orcid":"0000-0003-4843-3641","position":8,"is_corresponding":false},{"id":393076,"name":"Kristina M. Jordahl","orcid":"0000-0001-5165-5769","position":9,"is_corresponding":false},{"id":282206,"name":"Andrea Baccarelli","orcid":"0000-0002-3436-0640","position":10,"is_corresponding":false},{"id":218546,"name":"Lifang Hou","orcid":"0000-0003-4877-0031","position":11,"is_corresponding":false},{"id":275264,"name":"James D. Stewart","orcid":"0000-0002-2776-6570","position":12,"is_corresponding":false},{"id":24805,"name":"Yun Li","orcid":"0000-0002-9275-4189","position":13,"is_corresponding":false},{"id":61604,"name":"Michael J. Lamonte","orcid":"0000-0002-6669-5242","position":14,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":15,"is_corresponding":false},{"id":302270,"name":"Andrea Z. LaCroix","orcid":"0000-0002-9532-976X","position":16,"is_corresponding":false},{"id":487006,"name":"Purva Jain","orcid":"0000-0001-5236-8809","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:17.224217Z","pmid":"36107798","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}