{"doi":"10.1093/gerona/glac095","title":"Frailty and COVID-19 mRNA Vaccine Antibody Response in the COVID-19 Community Research Partnership","abstract":"BACKGROUND: COVID-19 has disproportionately affected older adults. Frailty has been associated with impaired vaccine response in other vaccine types, but the impact of frailty on mRNA vaccine response is undefined. METHODS: Observational study of adults aged 55 and older from 1 U.S. health care system between January 22, 2021 and September 16, 2021 with self-reported Moderna or Pfizer COVID-19 mRNA vaccine and an electronic frailty index (eFI) score from their medical record (n = 1 677). Participants' frailty status was compared with positive antibody detection (seroconversion) following full vaccination and subsequent loss of positive antibody detection (seroreversion) using logistic regression models. RESULTS: Of 1 677 older adults with median (interquartile range) age, 67 (62 and 72) years, and frailty status (nonfrail: 879 [52%], prefrail: 678 [40%], and frail: 120 [7.2%]), seroconversion was not detected in 23 (1.4%) over 60 days following full vaccination. Frail individuals were less likely to seroconvert than nonfrail individuals, adjusted odds ratio (OR) 3.75, 95% confidence interval (CI; 1.04, 13.5). Seroreversion was detected in 50/1 631 individuals (3.1%) over 6 months of median follow-up antibody testing. Frail individuals were more likely to serorevert than nonfrail individuals, adjusted OR 3.02, 95% CI (1.17, 7.33). CONCLUSION: Overall antibody response to COVID-19 mRNA vaccination was high across age and frailty categories. While antibody detection is an incomplete descriptor of vaccine response, the high sensitivity of this antibody combined with health-system data reinforce our conclusions that frailty is an independent predictor of impaired antibody response to the COVID-19 mRNA vaccines. Frailty should be considered in vaccine studies and prevention strategies.","journal":"The Journals of Gerontology Series A","year":2022,"id":247423,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7328,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":858602,"name":"Michael DeWitt","orcid":"0000-0001-8940-1967","position":1,"is_corresponding":false},{"id":307707,"name":"Kathryn E. Callahan","orcid":"0000-0001-6405-3062","position":2,"is_corresponding":false},{"id":71313,"name":"David M. Herrington","orcid":"0000-0002-7670-6400","position":3,"is_corresponding":false},{"id":322701,"name":"Martha A. Alexander‐Miller","orcid":"0000-0003-3455-0716","position":4,"is_corresponding":false},{"id":329227,"name":"Joshua Yukich","orcid":"0000-0002-6160-5295","position":5,"is_corresponding":false},{"id":885441,"name":"Iqra Munawar","orcid":null,"position":6,"is_corresponding":false},{"id":641442,"name":"Lewis McCurdy","orcid":null,"position":7,"is_corresponding":false},{"id":532967,"name":"Michael Gibbs","orcid":null,"position":8,"is_corresponding":false},{"id":594930,"name":"William S. Weintraub","orcid":"0000-0002-5384-5571","position":9,"is_corresponding":false},{"id":858609,"name":"John W. Sanders","orcid":"0000-0003-1077-6833","position":10,"is_corresponding":false},{"id":884988,"name":"Charles Semelka","orcid":"0000-0001-8137-1257","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35446945","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}