{"doi":"10.1093/gerona/glab376","title":"Higher Angiotensin II Type 1 Receptor Levels and Activity in the Postmortem Brains of Older Persons with Alzheimer’s Dementia","abstract":"Aging is a key risk factor in Alzheimer's dementia (AD) development and progression. The primary dementia-protective benefits of angiotensin II subtype 1 receptor (AT1R) blockers are believed to arise from systemic effects on blood pressure. However, a brain-specific renin-angiotensin system (b-RAS) exists, which can be altered by AT1R blockers. Brain RAS acts mainly through 3 angiotensin receptors: AT1R, AT2R, and AT4R. Changes in these brain angiotensin receptors may accelerate the progression of AD. Using postmortem frontal cortex brain samples of age- and sex-matched cognitively normal individuals (n = 30) and AD patients (n = 30), we sought to dissect the b-RAS changes associated with AD and assess how these changes correlate with brain markers of oxidative stress, inflammation, and mitochondrial dysfunction as well as amyloid-β and paired helical filament tau pathologies. Our results show higher protein levels of the pro-inflammatory AT1R and phospho-ERK (pERK) in the brains of AD participants. Brain AT1R levels and pERK correlated with higher oxidative stress, lower cognitive performance, and higher tangle and amyloid-β scores. This study identifies molecular changes in b-RAS and offers insight into the role of b-RAS in AD-related brain pathology.","journal":"The Journals of Gerontology Series A","year":2021,"id":172144,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":264348,"name":"Lolita S. Nidadavolu","orcid":"0000-0003-2433-0728","position":1,"is_corresponding":false},{"id":264349,"name":"Claudene J. George","orcid":"0000-0002-0710-027X","position":2,"is_corresponding":false},{"id":507310,"name":"Ruth Marx-Rattner","orcid":null,"position":3,"is_corresponding":false},{"id":576713,"name":"Laura Powell","orcid":null,"position":4,"is_corresponding":false},{"id":109431,"name":"Qian‐Li Xue","orcid":"0000-0001-8818-7444","position":5,"is_corresponding":false},{"id":668990,"name":"Jing Tian","orcid":"0000-0003-0741-8031","position":6,"is_corresponding":false},{"id":708300,"name":"Joy Salib","orcid":null,"position":7,"is_corresponding":false},{"id":264350,"name":"Esther S. Oh","orcid":"0000-0002-9638-5763","position":8,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":9,"is_corresponding":false},{"id":707730,"name":"Pervin Dinçer","orcid":"0000-0002-1704-6350","position":10,"is_corresponding":false},{"id":778,"name":"David A. Bennett","orcid":"0000-0003-3689-554X","position":11,"is_corresponding":false},{"id":57359,"name":"Jeremy Walston","orcid":"0000-0002-6965-2723","position":12,"is_corresponding":false},{"id":264351,"name":"Peter Abadir","orcid":"0000-0002-8186-0066","position":13,"is_corresponding":false},{"id":264347,"name":"Çağlar Coşarderelioğlu","orcid":"0000-0002-7560-1287","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:37.150824Z","pmid":"34914835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}