{"doi":"10.1093/gerona/glab296","title":"HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model","abstract":"To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model with a high level of ubiquitous expression of the naked mole-rat HspB1 protein. The worms showed increased life span under multiple conditions and also increased resistance to heat stress. RNAi experiments suggest that HspB1-induced life extension is dependent on the transcription factors skn-1 (Nrf2) and hsf-1 (Hsf1). RNAseq from HspB1 worms showed an enrichment in several skn-1 target genes, including collagen proteins and lysosomal genes. Expression of HspB1 also improved functional outcomes regulated by SKN-1, specifically oxidative stress resistance and pharyngeal integrity. This work is the first to link a small heat shock protein with collagen function, suggesting a novel role for HspB1 as a hub between canonical heat response signaling and SKN-1 transcription.","journal":"The Journals of Gerontology Series A","year":2021,"id":180653,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":730715,"name":"Erin Munkáscy","orcid":null,"position":1,"is_corresponding":false},{"id":730716,"name":"Haven Tillmon","orcid":null,"position":2,"is_corresponding":false},{"id":730717,"name":"Tamara Fraker","orcid":null,"position":3,"is_corresponding":false},{"id":730036,"name":"Jessica Scheirer","orcid":"0000-0003-3882-7604","position":4,"is_corresponding":false},{"id":504393,"name":"Deborah Holstein","orcid":"0000-0002-8412-200X","position":5,"is_corresponding":false},{"id":714040,"name":"Damian Lozano","orcid":"0000-0001-8078-7912","position":6,"is_corresponding":false},{"id":730718,"name":"Maruf Khan","orcid":null,"position":7,"is_corresponding":false},{"id":402296,"name":"Tali Gidalevitz","orcid":"0000-0002-9178-6648","position":8,"is_corresponding":false},{"id":504397,"name":"James D. Lechleiter","orcid":"0000-0001-9000-0722","position":9,"is_corresponding":false},{"id":730037,"name":"Alfred L. Fisher","orcid":"0000-0001-6451-2644","position":10,"is_corresponding":false},{"id":277075,"name":"Habil Zare","orcid":"0000-0001-5902-6238","position":11,"is_corresponding":false},{"id":730719,"name":"Karl A. Rodriguez","orcid":null,"position":12,"is_corresponding":false},{"id":730035,"name":"Courtney Alexander","orcid":"0000-0003-3718-5769","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:47:57.268805Z","pmid":"34610126","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}