{"doi":"10.1093/gerona/glab153","title":"Longitudinal Blood Pressure Patterns From Mid- to Late Life and Late-Life Hearing Loss in the Atherosclerosis Risk in Communities Study","abstract":"BACKGROUND: Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up. METHODS: Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression. RESULTS: Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing. CONCLUSIONS: Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.","journal":"The Journals of Gerontology Series A","year":2021,"id":199148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":702335,"name":"Kening Jiang","orcid":"0000-0002-4532-4469","position":1,"is_corresponding":false},{"id":685428,"name":"Simo Du","orcid":"0000-0001-9551-3754","position":2,"is_corresponding":false},{"id":650132,"name":"Joshua Betz","orcid":"0000-0003-4488-9799","position":3,"is_corresponding":false},{"id":482270,"name":"Nicholas S. Reed","orcid":"0000-0003-0410-6067","position":4,"is_corresponding":false},{"id":275267,"name":"Melinda C. Power","orcid":"0000-0001-9099-7964","position":5,"is_corresponding":false},{"id":328345,"name":"Rebecca F. Gottesman","orcid":"0000-0002-9504-1256","position":6,"is_corresponding":false},{"id":699682,"name":"A. Richey Sharrett","orcid":"0000-0002-8835-7770","position":7,"is_corresponding":false},{"id":90099,"name":"Michael Griswold","orcid":"0000-0001-8106-5516","position":8,"is_corresponding":false},{"id":34922,"name":"Keenan A. Walker","orcid":"0000-0002-5989-9853","position":9,"is_corresponding":false},{"id":291347,"name":"Edgar R. Miller","orcid":"0000-0003-0157-6258","position":10,"is_corresponding":false},{"id":633204,"name":"Frank R. Lin","orcid":"0000-0002-6458-1196","position":11,"is_corresponding":false},{"id":482269,"name":"Jennifer A. Deal","orcid":"0000-0002-6985-048X","position":12,"is_corresponding":false},{"id":775600,"name":"James Ting","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T23:50:36.595945Z","pmid":"34043799","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}