{"doi":"10.1093/gerona/glab093","title":"Elevated IL-6 and CRP Levels Are Associated With Incident Self-Reported Major Mobility Disability: A Pooled Analysis of Older Adults With Slow Gait Speed","abstract":"BACKGROUND: Elevated interleukine-6 (IL-6) and C-reactive protein (CRP) are associated with aging-related reductions in physical function, but little is known about their independent and combined relationships with major mobility disability (MMD), defined as the self-reported inability to walk a quarter mile. METHODS: We estimated the absolute and relative effect of elevated baseline IL-6, CRP, and their combination on self-reported MMD risk among older adults (≥68 years; 59% female) with slow gait speed (<1.0 m/s). Participants were MMD-free at baseline. IL-6 and CRP were assessed using a central laboratory. The study combined a cohort of community-dwelling high-functioning older adults (Health ABC) with 2 trials of low-functioning adults at risk of MMD (LIFE-P, LIFE). Analyses utilized Poisson regression for absolute MMD incidence and proportional hazards models for relative risk. RESULTS: We found higher MMD risk per unit increase in log IL-6 (hazard ratio [HR] = 1.26; 95% confidence interval [95% CI] 1.13-1.41). IL-6 meeting predetermined threshold considered to be high (>2.5 pg/mL) was similarly associated with higher risk of MMD (HR = 1.31; 95% CI 1.12-1.54). Elevated CRP (CRP >3.0 mg/L) was also associated with increased MMD risk (HR = 1.38; 95% CI 1.10-1.74). The CRP effect was more pronounced among participants with elevated IL-6 (HR = 1.62; 95% CI 1.12-2.33) compared to lower IL-6 levels (HR = 1.19; 95% CI 0.85-1.66). CONCLUSIONS: High baseline IL-6 and CRP were associated with an increased risk of MMD among older adults with slow gait speed. A combined biomarker model suggests CRP was associated with MMD when IL-6 was elevated.","journal":"The Journals of Gerontology Series A","year":2021,"id":176258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":260521,"name":"Stephen B. Kritchevsky","orcid":"0000-0003-3336-6781","position":1,"is_corresponding":false},{"id":242022,"name":"Thomas M. Gill","orcid":"0000-0002-6450-0368","position":2,"is_corresponding":false},{"id":235332,"name":"Walter T. Ambrosius","orcid":"0000-0002-6335-4303","position":3,"is_corresponding":false},{"id":330409,"name":"Stephen D. Anton","orcid":null,"position":4,"is_corresponding":false},{"id":109419,"name":"Roger A. Fielding","orcid":"0000-0003-2236-9020","position":5,"is_corresponding":false},{"id":823,"name":"­Abby C. King","orcid":"0000-0002-7949-8811","position":6,"is_corresponding":false},{"id":235334,"name":"W. Jack Rejeski","orcid":"0000-0003-2281-4649","position":7,"is_corresponding":false},{"id":394241,"name":"Laura Lovato","orcid":null,"position":8,"is_corresponding":false},{"id":42890,"name":"Mary Mcdermott","orcid":"0000-0002-3724-7619","position":9,"is_corresponding":false},{"id":57360,"name":"Anne B. Newman","orcid":"0000-0002-0106-1150","position":10,"is_corresponding":false},{"id":238660,"name":"Marco Pahor","orcid":null,"position":11,"is_corresponding":false},{"id":649000,"name":"Michael P. Walkup","orcid":null,"position":12,"is_corresponding":false},{"id":25028,"name":"Russell P. Tracy","orcid":"0000-0002-0080-2420","position":13,"is_corresponding":false},{"id":109416,"name":"Todd M. Manini","orcid":"0000-0002-5970-4462","position":14,"is_corresponding":false},{"id":388665,"name":"Daniel P. Beavers","orcid":"0000-0002-4286-9463","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:47:19.591542Z","pmid":"33822946","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}