{"doi":"10.1093/gerona/glaa308","title":"Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle","abstract":"Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.","journal":"The Journals of Gerontology Series A","year":2020,"id":74655,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390477,"name":"Ziad S. Mahmassani","orcid":"0000-0002-3391-6184","position":1,"is_corresponding":false},{"id":390478,"name":"Svyatoslav Dvoretskiy","orcid":"0000-0002-2583-7339","position":2,"is_corresponding":false},{"id":390479,"name":"Carmen Valero","orcid":"0000-0002-6620-8395","position":3,"is_corresponding":false},{"id":391585,"name":"Heather D. Huntsman","orcid":null,"position":4,"is_corresponding":false},{"id":391586,"name":"Samuel Lapp","orcid":null,"position":5,"is_corresponding":false},{"id":390480,"name":"Yu‐Fu Wu","orcid":"0000-0003-4452-1724","position":6,"is_corresponding":false},{"id":323425,"name":"Stephen D. Hauschka","orcid":"0000-0003-2425-2766","position":7,"is_corresponding":false},{"id":304186,"name":"Dean J. Burkin","orcid":"0000-0001-9228-5258","position":8,"is_corresponding":false},{"id":390481,"name":"Marni D. Boppart","orcid":"0000-0003-0369-6974","position":9,"is_corresponding":false},{"id":390476,"name":"Koyal Garg","orcid":"0000-0002-8353-0212","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:46:11.663457Z","pmid":"33284954","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}