{"doi":"10.1093/gerona/glaa121","title":"In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans","abstract":"The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of healthy human subjects. Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of human lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.","journal":"The Journals of Gerontology Series A","year":2020,"id":128650,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":579365,"name":"Srikant Sarangi","orcid":"0000-0003-0864-2924","position":1,"is_corresponding":false},{"id":579366,"name":"Danielle Ledoux","orcid":"0000-0002-4722-2677","position":2,"is_corresponding":false},{"id":579367,"name":"Juliet A. Moncaster","orcid":"0000-0002-7849-4325","position":3,"is_corresponding":false},{"id":579368,"name":"Douglas S Parsons","orcid":"0000-0001-6553-0262","position":4,"is_corresponding":false},{"id":579981,"name":"Kevin J Washicosky","orcid":null,"position":5,"is_corresponding":false},{"id":579982,"name":"Caitlin A Black","orcid":null,"position":6,"is_corresponding":false},{"id":579983,"name":"Frank J Weng","orcid":null,"position":7,"is_corresponding":false},{"id":18916,"name":"Maria Ericsson","orcid":"0000-0002-4563-3683","position":8,"is_corresponding":false},{"id":579984,"name":"Robert D Moir","orcid":null,"position":9,"is_corresponding":false},{"id":271279,"name":"Yorghos Tripodis","orcid":"0000-0003-2190-7608","position":10,"is_corresponding":false},{"id":579369,"name":"John I. Clark","orcid":"0000-0002-6651-5205","position":11,"is_corresponding":false},{"id":226532,"name":"Rudolph E. Tanzi","orcid":"0000-0002-7032-1454","position":12,"is_corresponding":false},{"id":579370,"name":"David G. Hunter","orcid":"0000-0002-4587-4794","position":13,"is_corresponding":false},{"id":297230,"name":"Lee E. Goldstein","orcid":"0000-0001-8419-9800","position":14,"is_corresponding":false},{"id":297219,"name":"Olga Minaeva","orcid":"0000-0002-7911-6510","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:42.522809Z","pmid":"32515825","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}