{"doi":"10.1093/genetics/iyae202","title":"The <i>C. elegans</i> LON-1 protein requires its CAP domain for function in regulating body size and BMP signaling","abstract":"The CAP (cysteine-rich secretory proteins, antigen-5, and pathogenesis-related) proteins are widely expressed and have been implicated to play diverse roles ranging from mammalian reproduction to plant immune response. Increasing evidence supports a role of CAP proteins in lipid binding. The Caenorhabditis elegans CAP protein LON-1 is known to regulate body size and bone morphogenetic protein (BMP) signaling. LON-1 is a secreted protein with a conserved CAP domain and a C-terminal unstructured domain with no homology to other proteins. In this study, we report that the C-terminal domain of LON-1 is dispensable for its function. Instead, key conserved residues located in the CAP domain are critical for LON-1 function in vivo. We further showed that LON-1 is capable of binding sterol, but not fatty acid, in vitro, and that certain key residues implicated in LON-1 function in vivo are also important for LON-1 sterol binding in vitro. These findings suggest a role of LON-1 in regulating body size and BMP signaling via sterol binding.","journal":"Genetics","year":2024,"id":482572,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1323097,"name":"Stéphanie Cottier","orcid":"0000-0002-8843-6946","position":1,"is_corresponding":false},{"id":964856,"name":"Lianzijun Wang","orcid":"0000-0001-6467-4387","position":2,"is_corresponding":false},{"id":1323529,"name":"Sergio Moreira-Antepara","orcid":null,"position":3,"is_corresponding":false},{"id":429471,"name":"Anthony Nzessi","orcid":null,"position":4,"is_corresponding":false},{"id":428615,"name":"Zhiyu Liu","orcid":"0000-0001-9918-189X","position":5,"is_corresponding":false},{"id":854796,"name":"Byron C. Williams","orcid":"0000-0002-1517-931X","position":6,"is_corresponding":false},{"id":964857,"name":"Myeongwoo Lee","orcid":"0000-0003-2652-3646","position":7,"is_corresponding":false},{"id":689018,"name":"Roger Schneiter","orcid":"0000-0002-9102-8396","position":8,"is_corresponding":false},{"id":428616,"name":"Jun Liu","orcid":"0000-0001-7815-4075","position":9,"is_corresponding":false},{"id":1323528,"name":"Maria Victoria Serrano","orcid":null,"position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:07:18.280369Z","pmid":"39657262","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}