{"doi":"10.1093/genetics/86.3.567","title":"EVIDENCE FOR A SET OF CLOSELY LINKED AUTOSOMAL GENES THAT INTERACT WITH SEX-CHROMOSOME HETEROCHROMATIN IN <i>DROSOPHILA MELANOGASTER</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>It is proposed that there exists a special region in the euchromatin of the left arm of chromosome 2 (contained within sections 31-32 of the standard salivary gland chromosome map) that is defined by a set of genes, each one of which interacts with a specific sex-chromosome heterochromatic segment. The evidence for the existence of this region is, first, the exhibition, mapping, and analysis of five different maternal-effect, embryonic semi-lethals located in region 31-32. Secondly, in each case the consequence of the maternal effect is markedly influenced by the amount of X- or Y-chromosome heterochromatin carried by the progeny of mutant mothers. The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed</jats:p>","journal":"Genetics","year":1977,"id":648937,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1263710,"name":"L Sandler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"EVIDENCE FOR A SET OF CLOSELY LINKED AUTOSOMAL GENES THAT INTERACT WITH SEX-CHROMOSOME HETEROCHROMATIN IN <i>DROSOPHILA MELANOGASTER</i>","abstract":"<jats:title>ABSTRACT</jats:title>\n               <jats:p>It is proposed that there exists a special region in the euchromatin of the left arm of chromosome 2 (contained within sections 31-32 of the standard salivary gland chromosome map) that is defined by a set of genes, each one of which interacts with a specific sex-chromosome heterochromatic segment. The evidence for the existence of this region is, first, the exhibition, mapping, and analysis of five different maternal-effect, embryonic semi-lethals located in region 31-32. Secondly, in each case the consequence of the maternal effect is markedly influenced by the amount of X- or Y-chromosome heterochromatin carried by the progeny of mutant mothers. The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed</jats:p>","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"408229","pmcid":"PMC1213695","openalex_id":"https://openalex.org/W2116283001","authors":[],"funders":[],"total_grants":0,"fwci":1.617,"citation_percentile":0.8288117,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"https://academic.oup.com/genetics/article-pdf/86/3/567/35644868/genetics0567.pdf","host_type":"journal"},{"url":"https://academic.oup.com/genetics/article-pdf/86/3/567/35644868/genetics0567.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/genetics/article-pdf/86/3/567/35644868/genetics0567.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/genetics/86.3.567","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/408229","host_type":"repository"}],"fields_of_study":["Genomics and Chromatin Dynamics","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Chromosomal and Genetic Variations"],"mesh_terms":["Animals","Chromosome Mapping","Drosophila melanogaster","Extrachromosomal Inheritance","Female","Genes","Heterochromatin","Genetic Linkage","Male","Mutation","Phenotype","Sex Chromosomes"],"keywords":["Euchromatin","Heterochromatin","Biology","Genetics","Drosophila melanogaster","Chromosome","X chromosome","Gene","Y chromosome","Chromosome 4"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T03:08:19.268288Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}